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oai:repisalud.isciii.es:20.500.12105/225642024-11-29T06:41:58Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Terrasa, Juan Lorenzo author Montoya, Pedro author González-Roldán, Ana María author Sitges, Carolina author 2018-07-12 The capacity to suppress irrelevant incoming input, termed sensory gating, is one of the most investigated inhibitory processes associated with cognitive impairments due to aging. The aim of this study was to examine the influence of aging on sensory gating by using somatosensory event-related potentials (ERPs) elicited by repetitive non-painful tactile stimulation (paired-pulsed task). Somatosensory ERPs were recorded in 20 healthy young adults and 20 healthy older adults while they received two identical pneumatic stimuli (S1 and S2) of 100 ms duration with an inter-stimulus interval of 550 +/- 50 ms on both forefingers. The difference between the somatosensory ERPs amplitude elicited by S1 and S2 was computed as a sensory gating measure. The amplitude and the latency of P50, N100 and late positive complex (LPC) were analyzed as well as the source generators of the gating effect. Reduced sensory gating was found in older individuals for N100 at frontal and centro-parietal electrodes and for LPC at fronto-central electrodes. Source localization analyses also revealed a reduced current density during gating effect in the older group in frontal areas in N100 and LPC. Moreover, older individuals showed delayed latencies in N100. No significant gating effect differences were found between groups in P50. These findings suggest an age-related slowing of processing speed and a reduced efficiency of inhibitory mechanisms in response to repetitive somatosensory information during stimulus evaluation, and a preservation of processing speed and inhibitory control during early stimulus coding in aging. Terrasa Navarro JL, Montoya P, Gonzalez Roldan AM, Sitges Quiros C. Inhibitory Control Impairment on Somatosensory Gating Due to Aging: An Event-Related Potential Study. Front Hum Neurosci. 2018 Jul 12;12:280. 10.3389/fnhum.2018.00280 1662-5161 Frontiers in Human Neuroscience http://hdl.handle.net/20.500.13003/9216 30050421 L624298557 2-s2.0-85054779928 https://hdl.handle.net/20.500.12105/22564 438412800002 Aging Somatosensory gating Paired-pulse task Event-related potential Source localization Inhibitory deficit hypothesis Inhibitory Control Impairment on Somatosensory Gating Due to Aging: An Event-Related Potential Study