2026-06-14T02:27:56Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/225542024-11-28T23:30:49Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Rodríguez, Adrián author Saez-Torres, Concepcion author Mir Perelló, Maria Concepción author Casasayas-Carles, Paula author Rodriguez-Garcia, Nuria author Rodrigo, Dolores author Frontera-Juan, Guillem author Buades-Fuster, Juan Manuel author Gómez Cobo, Cristina author Costa-Bauza, Antonia author Grases, Felix author 2018-12-19 Background: The diagnosis and follow-up of stone forming patients is usually performed by analysis of 24-h urine samples. However, crystallization risk varies throughout the day, being higher at night. The main objective of this study is to evaluate the urinary crystallization risk in adults and children by calculating risk indexes based on different collection periods. Methods: The study included 149 adults (82 healthy and 67 stone-formers) and 108 children (87 healthy and 21 stone-formers). 24-h urine was collected, divided into 12-hdaytime sample (8am to 8pm), and 12-h overnight sample (8pm to 8am next morning). Solute concentrations, the calcium to citrate ratio (Ca/Cit), and the ion activity product of calcium oxalate (AP[CaOx]) and calcium phosphate (AP[CaP]) were calculated in each 12-h sample and in overall 24-h urine. Assessments were also related to stone type.ResultsCa/Cit and AP(CaOx) were significantly higher in stone forming patients than in healthy subjects. The 12-h overnight samples had the highest values for both risk indexes, confirming a greater risk for crystallization at night. The AP(CaP) index was significantly higher in patients with pure hydroxyapatite stones than healthy controls, but was not significantly different between stone-formers overall and healthy controls. Conclusions: The calculation of risk indexes is a simple method that clinicians can use to estimate crystallization risk. For this purpose, the use of 12-h overnight urine may be a reliable alternative to 24-h collections. Rodriguez A, Saez-Torres Barroso MC, Mir Perello MC, Casasayas P, Rodriguez N, Rodrigo Jiménez MD, et al. Effect of sample time on urinary lithogenic risk indexes in healthy and stone-forming adults and children. BMC Urol. 2018 Dec 19;18:116. 10.1186/s12894-018-0430-8 1471-2490 BMC Urology http://hdl.handle.net/20.500.13003/8975 30567525 L625556017 2-s2.0-85058875132 https://hdl.handle.net/20.500.12105/22554 453874700001 12-h night urine AP(CaOx) index AP(CaP) index Ca Cit ratio Crystallization risk Renal Lithiasis Effect of sample time on urinary lithogenic risk indexes in healthy and stone-forming adults and children