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00925njm 22002777a 4500 dc Schroder, Helmut author Cardenas-Fuentes, Gabriela author Angel Martinez-Gonzalez, Miguel author Corella, Dolores author Vioque, Jesus author Romaguera, Dora author Alfredo Martinez, J author Tinahones, Francisco J author Lopez Miranda, Jose author Estruch, Ramon author Bueno-Cavanillas, Aurora author Aros, Fernando author Marcos, Ascension author Tur, Josep A author Warnberg, Julia author Serra-Majem, Lluis author Martín, Vicente author Vazquez, Clotilde author Lapetra, Jose author Pinto, Xavier author Vidal, Josep author Daimiel, Lidia author Juan Gaforio, Jose author Matia-Martin, Pilar author Ros, Emilio author Castaner, Olga author Lassale, Camille author Ruiz-Canela, Miguel author Asensio, Eva M author Basora, Josep author Torres-Collado, Laura author Garcia-Rios, Antonio author Abete, Itziar author Toledo, Estefanía author Buil-Cosiales, Pilar author Bullo, Monica author Goday, Albert author Fito, Montserrat author Salas-Salvado, Jordi author PREDIMED-Plus Investigators author 2018-11-13 Background:The development and implementation of effective physical activity (PA) intervention programs is challenging, particularly in older adults. After the first year of the intervention program used in the ongoing PREvencion con DIeta MEDiterranea (PREDIMED)-Plus trial, we assessed the initial effectiveness of the PA component. Methods: PREDIMED-Plus is an ongoing randomized clinical trial including 6874 participants randomized to an intensive weight-loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support and to a control group using MedDiet recommendations but without calorie restriction or PA advice. Body mass index (BMI) and waist circumference (WC) are measured by standard clinical protocols. Duration and intensity of PA is self-reported using the validated REGICOR Short Physical Activity Questionnaire. The primary endpoint of the PREDIMED-Plus trial is a combined cardiovascular outcome: myocardial infarction (acute coronary syndromes with positive troponin test), stroke, or cardiovascular mortality. The present study involved secondary analysis of PA data (n=6059; mean age 654.9years) with one-year changes in total, light, and moderate-to-vigorous PA within and between intervention groups as the outcome. Generalized estimating equation models were fitted to evaluate time trends of PA, BMI, and WC within groups and differences between intervention and control groups. Results: After 12months, average daily MVPA increased by 27.2 (95%CI 5.7;48.7) METs-min/day and 123.1 (95%CI 109.7-136.6) METs-min/day in the control and intervention groups, respectively. Total-PA, light-PA, and MVPA increased significantly (p<0.01) in both groups. A significant (p<0.001) time*intervention group interaction was found for Total-PA and MVPA, meaning the PA trajectory over time differed between the intervention and control groups. Age, sex, education level, and BMI did not moderate the effectiveness of the PA intervention. BMI and WC decreased significantly with increasing MVPA, compared with participants who reported no changes in MVPA. Conclusion: After one year of follow-up, the PREDIMED-Plus PA intervention has been effective in increasing daily PA in older adults.Trial registration Retrospectively registered at the International Standard Randomized Controlled Trial (http://www.isrctn.com/ISRCTN89898870), registration date: 24 July 2014. Schroder H, Cardenas-Fuentes G, Martinez-Gonzalez MA, Corella D, Vioque J, Romaguera D, et al. Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial. Int J Behav Nutr Phys Act. 2018 Nov 13;15:110. 10.1186/s12966-018-0741-x 1479-5868 International Journal of Behavioral Nutrition and Physical Activity http://hdl.handle.net/20.500.13003/9023 30424822 L624971455 2-s2.0-85056549248 https://hdl.handle.net/20.500.12105/22553 450173500001 Randomized control trial Physical activity Older adults Intervention program Body mass index Waist circumference Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial