2026-07-23T19:32:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/225422024-11-28T17:30:47Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967
Repisalud
author
Toledo Pons, Nuria
author
Noell, Guillaume
author
Jahn, Andreas
author
Iglesias, Amanda
author
Duran Pastor, Maria Antonia
author
Iglesias, Julio
author
Rios, Angel
author
Scrimini, Sergio
author
Faner, Rosa
author
Gigirey, Orlando
author
Agusti, Alvar
author
García-Cosío, Borja
2024-09-06T09:53:47Z
2024-09-06T09:53:47Z
2018-06-15
Toledo-Pons N, Noell G, Jahn A, Iglesias A, Duran MA, Iglesias J, et al. Bone marrow characterization in COPD: a multi-level network analysis. Respir Res. 2018 Jun 15;19:118.
10.1186/s12931-018-0824-x
1465-9921
1465-993X
Respiratory Research
http://hdl.handle.net/20.500.13003/9250
29903047
L622570921
2-s2.0-85048634240
https://hdl.handle.net/20.500.12105/22542
435382700001
Background: Bone marrow (BM) produces hematopoietic and progenitor cells that contribute to distant organ inflammation and repair. Chronic obstructive pulmonary disease (COPD) is characterized by defective lung repair. Yet, BM composition has not been previously characterized in COPD patients. Methods: In this prospective and controlled study, BM was obtained by sternum fine-needle aspiration in 35 COPD patients and 25 healthy controls (10 smokers and 15 never-smokers). BM cell count and immunophenotype were determined by microscopy and flow cytometry, respectively. Circulating inflammatory (C-reactive protein, IL-6, IL-8) and repair markers (HGF, IGF, TGF-beta, VEGF) were quantified by ELISA. Results were integrated by multi-level network correlation analysis. Results: We found that: (1) there were no major significant pair wise differences between COPD patients and controls in the BM structural characteristics; (2) multi-level network analysis including patients and controls identifies a relation between immunity, repair and lung function not previously described, that remains in the COPD network but is absent in controls; and (3) this novel network identifies eosinophils as a potential mediator relating immunity and repair, particularly in patients with emphysema. Conclusions: Overall, these results suggest that BM is activated in COPD with impaired repair capacity in patients with more emphysema and/or higher circulating eosinophils.
eng
COPD
Bone marrow
Eosinophil
Network
Bone marrow characterization in COPD: a multi-level network analysis
research article