2026-07-23T23:05:04Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/225292024-11-28T17:27:34Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16960col_20.500.12105_16967
Repisalud
author
Gomez-Marcos, Manuel A
author
Gomez-Sanchez, Leticia
author
Carmen Patino-Alonso, Maria
author
Recio-Rodriguez, Jose I
author
Gomez-Sanchez, Marta
author
Reigada Mendez, Rebeca
author
Marti, Ruth
author
Agudo-Conde, Cristina
author
Ramos-Asensio, Rafael
author
Rodriguez-Sanchez, Emiliano
author
Maderuelo-Fernandez, Jose A
author
Garcia-Ortiz, Luis
author
MARK Grp
2024-09-06T09:53:41Z
2024-09-06T09:53:41Z
2018-11
Gomez-Marcos MA, Gomez-Sanchez L, Patino-Alonso MC, Recio-Rodriguez JI, Gomez-Sanchez M, Rigo Carratala F, et al. A body shape index and vascular structure and function in Spanish adults (MARK study) A cross-sectional study. Medicine (Baltimore). 2018 Nov;97(47):e13299.
10.1097/MD.0000000000013299
1536-5964
0025-7974
Medicine
http://hdl.handle.net/20.500.13003/17274
30461641
L627391415
2-s2.0-85056803177
https://hdl.handle.net/20.500.12105/22529
452464700042
A body shape index (ABSI) has been introduced as a marker of the relationship between body composition and all-cause mortality. However, until now, the relationships between ABSI and vascular structure and function have not been evaluated. The aim of this study was to investigate the association of ABSI with vascular structure and function in Spanish adults with intermediate cardiovascular risk. This cross-sectional study analyzed the data of 2354 subjects [age, 35-74 years (median, 62.0 years [range, 56.0-67.0 years]), 61.9% men] enrolled into the MediAte Risk management (MARK) study. ABSI was calculated by using the following formula: ABSI=waist circumference (m)/[body mass index(2/3) x height (m)(1/2))]. Vascular function was assessed by measuring cardio-ankle vascular index (CAVI) with the VaSera device and brachial ankle pulse wave velocity (baPWV) by using a validated equation. Vascular structure was assessed by measuring carotid intima-media thickness (IMT) by ultrasonography. Median value of ABSI was 0.083 (range, 0.081-0.090), mean CAVI was (8.5 +/- 1.2), and median IMT was 0.727 (range, 0.672-0.799). The values of ABSI and CAVI were higher in men. After adjusting for confounders, ABSI was positively associated with CAVI, baPWV, and average mean IMT. Thus, for each unit increase in ABSI, CAVI increased by 0.16 units, baPWV by 0.25m/s, and IMT by 0.033mm. In the logistic regression analysis, the odds ratio of ABSI was>1 for high CAVI >= 9, baPWV >= 15m/s, and IMT >= 0.90mm in the overall subject group, and in the sex-and age-specific (>62 years, <= 62 years) subgroups, after adjusting for confounders. The area under the receiver-operating characteristic curve of the ABSI was 0.631 (95% confidence interval [CI], 0.608-0.654) for CAVI >= 9, and 0.617 (95% CI, 0.593-0.641) for high baPWV >= 15m/s. ABSI showed a positive association with vascular structure and function, independent of other confounders that might influenceweight and fat mass distribution in Spanish subjects at intermediate cardiovascular risk.
eng
A body shape index
Brachial ankle pulse wave velocity
Cardio ankle vascular index
Carotid intima media thickness
Intermediate cardiovascular risk
A body shape index and vascular structure and function in Spanish adults (MARK study) A cross-sectional study
research article