2026-04-29T13:12:14Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/225222024-11-29T03:03:50Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Liakoni, Evangelia author Yates, Christopher author Dines, Alison M author Dargan, Paul I author Heyerdahl, Fridtjof author Hovda, Knut Erik author Wood, David M author Eyer, Florian author Liechti, Matthias E author Euro-Den Plus Res Grp author 2018-02 The aim of the study was to compare self-reported and analytically confirmed substance use in cases of acute recreational drug toxicity. We performed a retrospective analysis of emergency department presentations of acute recreational drug toxicity over 2 years (October 2013 to September 2015) within the European Drug Emergencies Network Plus project. Among the 10,956 cases of acute recreational drug toxicity during the study period, 831 could be included. Between the self-reported substance use and the toxicological results, the highest agreement was found for heroin (86.1%) and cocaine (74.1%), whereas inhalants, poppers, and magic mushrooms were self-reported but not analytically detected. Cathinones and other new psychoactive substances (NPS) could be detected using additional analytical methods. Among cases with both immunoassay (IA) and confirmation with mass spectrometry (MS), the results were consistent for methadone (100%) and cocaine (95.5%) and less consistent for amphetamines (81.8%). In cases with a positive IA for amphetamines (n=54), MS confirmed the presence of 3,4-methylenedioxymethamphetamine (MDMA), amphetamine, methamphetamine, and NPS in 37, 20, 10, and 6 cases, respectively, also revealing use of more than 1 substance in some cases. MS yielded positive results in 21 cases with a negative IA for amphetamines, including amphetamine, MDMA, methamphetamine, and NPS, in 14, 7, 2, and 2 cases, respectively. In conclusion, the highest agreement was found between self-reports and analytical findings for heroin and cocaine. The diagnosis of NPS use was mainly based on self-report. The IAs accurately identified methadone and cocaine, and MS had advantages for the detection of NPS and amphetamine derivatives. Liakoni E, Yates C, Dines AM, Dargan PI, Heyerdahl F, Hovda Knut E, et al. Acute recreational drug toxicity Comparison of self-reports and results of immunoassay and additional analytical methods in a multicenter European case series. Medicine (Baltimore). 2018 Feb;97(5):e9784. 10.1097/MD.0000000000009784 1536-5964 0025-7974 Medicine http://hdl.handle.net/20.500.13003/17288 29384873 L620854202 2-s2.0-85041684172 https://hdl.handle.net/20.500.12105/22522 428565900035 Acute recreational drug toxicity Chromatography Emergency department Immunoassay Mass spectrometry Acute recreational drug toxicity Comparison of self-reports and results of immunoassay and additional analytical methods in a multicenter European case series