2026-05-20T22:56:55Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/205222024-09-28T03:13:16Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Vázquez Alberdi, Lucia
author
Martínez-Busi, Marcela
author
Arrarte, Eloisa
author
Echeverry, Carolina
author
Calero, Miguel
author
Kun, Alejandra
funder
Agencia Nacional de Investigación e Innovación (Uruguay)
funder
Consejo Superior de Investigaciones Científicas (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas)
2024-07-12T07:30:49Z
2024-07-12T07:30:49Z
2024-05-07
Discov Nano. 2024 May 7;19(1):81.
10.1186/s11671-024-04023-7
2731-9229
Discover nano
38714630
http://hdl.handle.net/20.500.12105/20522
Curcumin is a polyphenol extracted from Curcuma longa's roots. Low doses of curcumin are related to anti-inflammatory, antioxidant, and neuroprotective effects, while high doses are used for their lethality. This diversity of behaviors allows us to understand curcumin as a compound with hormetic action. Due to its strongly hydrophobic character, curcumin is often solubilized in organic compounds. In this way, we have recently reported the undesirable and occasionally irreversible effects of alcohol and DMSO on the viability of primary Schwann cell cultures. In this scenario, the use of nanoparticles as delivery systems has become a successful alternative strategy for these compounds. In the present work, we describe the structure of Polydopamine (PDA) nanoparticles, loaded with a low dose of curcumin (Curc-PDA) without the use of additional organic solvents. We analyzed the curcumin released, and we found two different forms of curcumin. Small increased cell viability and proliferation were observed in endoneurial fibroblast and Schwann cell primary cultures when Curc-PDA was steadily supplied for 5 days. The increased bioavailability of this natural compound and the impact on cells in culture not only confirm the properties of curcumin at very low doses but also provide a glimpse of a possible therapeutic alternative for PNS conditions in which SCs are involved.
eng
Curcumin
Polydopamine-nanoparticles
Hormesis
Viability
Proliferation
A low dose of curcumin-PDA nanoparticles improves viability and proliferation in endoneurial fibroblasts and Schwann cell cultures
research article
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URL
https://repisalud.isciii.es/bitstreams/335c129d-c381-4cb9-8a68-0bafbe675ef1/download
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LowDoseCurcumin-PDA_Nanoparticles_2024.pdf
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Supplementary_LowDoseCurcumin-PDA_Nanoparticles_2024.pdf
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LowDoseCurcumin-PDA_Nanoparticles_2024.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/47ddf909-5f98-4dcc-8e65-c34730ed5995/download
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Supplementary_LowDoseCurcumin-PDA_Nanoparticles_2024.pdf.txt