2026-04-29T02:37:41Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/205202025-01-03T13:11:07Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Campuzano, Susana
author
Pedrero, María
author
Barderas Manchado, Rodrigo
author
Pingarrón, José M
funder
Conferencia de Rectores de las Universidades Españolas
funder
Consejo Superior de Investigaciones Científicas (España)
funder
Agencia Estatal de Investigación (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Comisión Europea. H2020
2024-07-12T07:09:06Z
2024-07-12T07:09:06Z
2024
Anal Bioanal Chem. 2024 Dec;416(30):7225-7247.
http://hdl.handle.net/20.500.12105/20520
38639792
10.1007/s00216-024-05294-w
1618-2650
Analytical and bioanalytical chemistry
Electrochemical biosensing continues to advance tirelessly, overcoming barriers that have kept it from leaving research laboratories for many years. Among them, its compromised performance in complex biological matrices due to fouling or receptor stability issues, the limitations in determining toxic and small analytes, and its use, conditioned to the commercial availability of commercial receptors and the exploration of natural molecular interactions, deserved to be highlighted. To address these challenges, in addition to the intrinsic properties of electrochemical biosensing, its coupling with biomimetic materials has played a fundamental role, among which bioinspired phage and peptide probes stand out. The versatility in design and employment of these probes has opened an unimaginable plethora of possibilities for electrochemical biosensing, improving their performance far beyond the development of highly sensitive and selective devices. The state of the art offers robust electroanalytical biotools, capable of operating in complex samples and with exciting opportunities to discover and determine targets regardless of their toxicity and size, the commercial availability of bioreceptors, and prior knowledge of molecular interactions. With all this in mind, this review offers a panoramic, novel, and updated vision of both the tremendous advances and opportunities offered by the combination of electrochemical biosensors with bioinspired phage and peptide probes and the challenges and research efforts that are envisioned in the immediate future.
eng
Electrochemical biosensing
Peptides
Phage probes
Phage display
Mimotopes
Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes
review article
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URL
https://repisalud.isciii.es/bitstreams/dee69f77-df8a-488a-aa84-78f560276c57/download
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BreakingBarriersElectrochemicalBiosensing_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/4276a189-5f1f-4532-8d00-a4235e777753/download
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BreakingBarriersElectrochemicalBiosensing_2024.pdf.txt