2026-05-04T19:32:47Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/205192024-11-28T19:28:36Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16966
Repisalud
author
Perez-Garcia, Covadonga
author
Sempere, Julio
author
Miguel, Sara de
author
Hita, Samantha
author
Úbeda, Aída
author
Vidal-Alcántara, Erick Joan
author
Llorente, Joaquín
author
Limia, Aurora
author
Gil-de-Miguel, Ángel
author
Sanz, Juan Carlos
author
Martinón-Torres, Federico
author
Ardanuy, Carmen
author
Domenech Lucas, Mirian
author
Yuste, Jose Enrique
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Merck, Sharp & Dohme
2024-07-12T06:13:47Z
2024-07-12T06:13:47Z
2024-06-19
J Infect. 2024 Jun 19;89(2):106204.
10.1016/j.jinf.2024.106204
1532-2742
The Journal of infection
38906265
http://hdl.handle.net/20.500.12105/20519
Objectives: Dynamic trends of invasive pneumococcal disease (IPD) including the evolution of prevalent serotypes are very useful to evaluate the impact of current and future pneumococcal conjugate vaccines (PCVs) and the rise of non-vaccine serotypes. In this study, we include epidemiological patterns of S. pneumoniae before and after COVID-19 pandemic. Methods: We characterized all national IPD isolates from children and adults received at the Spanish Pneumococcal Reference Laboratory during 2019-2023. Results: In the first pandemic year 2020, we found a general reduction in IPD cases across all age groups, followed by a partial resurgence in children in 2021 but not in adults. By 2022, IPD cases in children had returned to pre-pandemic levels, and partially in adults. In 2023, IPD rates surpassed those of the last pre-pandemic year. Notably, the emergence of serotype 3 is of significant concern, becoming the leading cause of IPD in both pediatric and adult populations over the last two years (2022-2023). Increase of serotype 4 in young adults occurred in the last epidemiological years. Conclusions: The COVID-19 pandemic led to a temporary decline in all IPD cases during 2020 attributable to non-pharmaceutical interventions followed by a subsequent rise. Employing PCVs with broader coverage and/or enhanced immunogenicity may be critical to mitigate the marked increase of IPD.
eng
S. pneumoniae
IPD
COVID-19
PCVs
Serotype 3
Serotype 4
Surveillance of invasive pneumococcal disease in Spain exploring the impact of the COVID-19 pandemic (2019-2023)
research article
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