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oai:repisalud.isciii.es:20.500.12105/204532025-04-23T11:24:59Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16974

00925njm 22002777a 4500 dc Lewis, Kate Marie author Ruiz, Milagros author Goldblatt, Peter author Morrison, Joana author Porta, Daniela author Forastiere, Francesco author Hryhorczuk, Daniel author Zvinchuk, Oleksandr author Saurel-Cubizolles, Marie-Josephe author Lioret, Sandrine author Annesi-Maesano, Isabella author Vrijheid, Martine author Torrent Quetglas, Maties author Iniguez, Carmen author Larranaga, Isabel author Harskamp-van Ginkel, Margreet W author Vrijkotte, Tanja GM author Klánová, Jana author Svancara, Jan author Barross, Henrique author Correia, Sofia author Jarvelin, Marjo-Riitta author Taanila, Anja author Ludvigsson, Johnny author Faresjo, Tomas: author Marmot, Michael author Pikhart, Hynek author 2017-09 Highly prevalent and typically beginning in childhood, asthma is a burdensome disease, yet the risk factors for this condition are not clarified. To enhance understanding, this study assessed the cohort-specific and pooled risk of maternal education on asthma in children aged 3-8 across 10 European countries. Data on 47,099 children were obtained from prospective birth cohort studies across 10 European countries. We calculated cohort-specific prevalence difference in asthma outcomes using the relative index of inequality (RII) and slope index of inequality (SII). Results from all countries were pooled using random-effects meta-analysis procedures to obtain mean RII and SII scores at the European level. Final models were adjusted for child sex, smoking during pregnancy, parity, mother's age and ethnicity. The higher the score the greater the magnitude of relative (RII, reference 1) and absolute (SII, reference 0) inequity. The pooled RII estimate for asthma risk across all cohorts was 1.46 (95% CI 1.26, 1.71) and the pooled SII estimate was 1.90 (95% CI 0.26, 3.54). Of the countries examined, France, the United Kingdom and the Netherlands had the highest prevalence's of childhood asthma and the largest inequity in asthma risk. Smaller inverse associations were noted for all other countries except Italy, which presented contradictory scores, but with small effect sizes. Tests for heterogeneity yielded significant results for SII scores. Overall, offspring of mothers with a low level of education had an increased relative and absolute risk of asthma compared to offspring of high-educated mothers. Lewis KM, Ruiz M, Goldblatt P, Morrison J, Porta D, Forastiere F, et al. Mother's education and offspring asthma risk in 10 European cohort studies. Eur J Epidemiol. 2017 Sep;32(9):797-805. Epub 2017 Sep 19. 10.1007/s10654-017-0309-0 1573-7284 0393-2990 European Journal of Epidemiology http://hdl.handle.net/20.500.13003/9690 28929268 L618364308 2-s2.0-85029597056 http://hdl.handle.net/20.500.12105/20453 414156900007 Asthma Children Cohort studies Maternal education Socioeconomic position Disease risk Mother's education and offspring asthma risk in 10 European cohort studies