2026-08-29T19:27:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/204502024-11-28T17:21:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16960col_20.500.12105_16967
Repisalud
author
Gomez-Sanchez, Leticia
author
Garcia-Ortiz, Luis
author
Patino-Alonso, Maria C
author
Recio-Rodriguez, Jose I
author
Reigada Mendez, Rebeca
author
Marti, Ruth
author
Agudo-Conde, Cristina
author
Rodriguez-Sanchez, Emiliano
author
Maderuelo-Fernandez, Jose A
author
Ramos-Asensio, Rafael
author
Gomez-Marcos, Manuel A
author
MARK Grp
2024-07-11T09:10:41Z
2024-07-11T09:10:41Z
2017-09
Gomez-Sanchez L, Garcia-Ortiz L, Patino-Alonso MC, Recio-Rodriguez JI, Rigo Carratala F, Marti R, et al. Adiposity measures and arterial stiffness in primary care: the MARK prospective observational study. BMJ Open. 2017 Sep;7(9):e016422.
10.1136/bmjopen-2017-016422
2044-6055
BMJ Open
http://hdl.handle.net/20.500.13003/9688
28963288
L618501605
2-s2.0-85030231085
http://hdl.handle.net/20.500.12105/20450
412650700130
Background The cardiovascular risk of obesity is potentially increased by arterial stiffness. Objective To assess the relationship of adiposity measures with arterial stiffness in Caucasian adults with intermediate cardiovascular risk. Setting Six Spanish health centres. Participants We enrolled 2354 adults (age range, 3574 years; mean age, 61.4 +/- 7.7 years, 61.9% male). Methods This is a cross-sectional study that analyses data from the baseline visit of the improving interMediAte RisK management (MARK) study. The main outcome variables were body mass index (BMI), waist-to-height ratio (WHtR), Clinica Universidad de Navarra-body adiposity estimation (CUN-BAE) body fat percentage and body roundness index (BRI). Vascular function was assessed by the cardio-ankle vascular index (CAVI) with the VaSera device; brachialankle pulse wave velocity (baPWV) was determined using a validated equation. Results The mean adiposity measures were a BMI of 29.2 +/- 4.4, WHtR of 0.61 +/- 0.07, CUN-BAE of 35.7 +/- 1.7 and BRI of 5.8 +/- 1.7. The mean stiffness measures were a CAVI of 8.8 +/- 1.2 and baPWV of 14.9 +/- 2.5. In multiple linear regression analyses, all adiposity measures were negatively associated with CAVI and baPWV (p< 0.01 for all) after adjustment for possible factors of confusion. The proportion of CAVI variability via the adiposity measures were 5.5% for BMI, 5.8% for CUN-BAE, 3.8% for WHtR and 3.7% for BRI. These were higher among diabetic, obese, younger (<= 62 years) and non-hypertensive subjects who had similar activity and sedentary profiles. Conclusions Adiposity measures are negatively associated with arterial stiffness measures. The percentage of variation in CAVI explained by its relation to the different measures of adiposity ranges from 5.8% (CUN-BAE) to 3.7% (BRI). In the case of baPWV, it oscillates between 0.7% (CUN-BAE and BMI) and 0.1% (WHtR).
eng
Adiposity measures and arterial stiffness in primary care: the MARK prospective observational study
research article