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oai:repisalud.isciii.es:20.500.12105/204502024-11-28T17:21:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16960col_20.500.12105_16967

00925njm 22002777a 4500 dc Gomez-Sanchez, Leticia author Garcia-Ortiz, Luis author Patino-Alonso, Maria C author Recio-Rodriguez, Jose I author Reigada Mendez, Rebeca author Marti, Ruth author Agudo-Conde, Cristina author Rodriguez-Sanchez, Emiliano author Maderuelo-Fernandez, Jose A author Ramos-Asensio, Rafael author Gomez-Marcos, Manuel A author MARK Grp author 2017-09 Background The cardiovascular risk of obesity is potentially increased by arterial stiffness. Objective To assess the relationship of adiposity measures with arterial stiffness in Caucasian adults with intermediate cardiovascular risk. Setting Six Spanish health centres. Participants We enrolled 2354 adults (age range, 3574 years; mean age, 61.4 +/- 7.7 years, 61.9% male). Methods This is a cross-sectional study that analyses data from the baseline visit of the improving interMediAte RisK management (MARK) study. The main outcome variables were body mass index (BMI), waist-to-height ratio (WHtR), Clinica Universidad de Navarra-body adiposity estimation (CUN-BAE) body fat percentage and body roundness index (BRI). Vascular function was assessed by the cardio-ankle vascular index (CAVI) with the VaSera device; brachialankle pulse wave velocity (baPWV) was determined using a validated equation. Results The mean adiposity measures were a BMI of 29.2 +/- 4.4, WHtR of 0.61 +/- 0.07, CUN-BAE of 35.7 +/- 1.7 and BRI of 5.8 +/- 1.7. The mean stiffness measures were a CAVI of 8.8 +/- 1.2 and baPWV of 14.9 +/- 2.5. In multiple linear regression analyses, all adiposity measures were negatively associated with CAVI and baPWV (p< 0.01 for all) after adjustment for possible factors of confusion. The proportion of CAVI variability via the adiposity measures were 5.5% for BMI, 5.8% for CUN-BAE, 3.8% for WHtR and 3.7% for BRI. These were higher among diabetic, obese, younger (<= 62 years) and non-hypertensive subjects who had similar activity and sedentary profiles. Conclusions Adiposity measures are negatively associated with arterial stiffness measures. The percentage of variation in CAVI explained by its relation to the different measures of adiposity ranges from 5.8% (CUN-BAE) to 3.7% (BRI). In the case of baPWV, it oscillates between 0.7% (CUN-BAE and BMI) and 0.1% (WHtR). Gomez-Sanchez L, Garcia-Ortiz L, Patino-Alonso MC, Recio-Rodriguez JI, Rigo Carratala F, Marti R, et al. Adiposity measures and arterial stiffness in primary care: the MARK prospective observational study. BMJ Open. 2017 Sep;7(9):e016422. 10.1136/bmjopen-2017-016422 2044-6055 BMJ Open http://hdl.handle.net/20.500.13003/9688 28963288 L618501605 2-s2.0-85030231085 http://hdl.handle.net/20.500.12105/20450 412650700130 Adiposity measures and arterial stiffness in primary care: the MARK prospective observational study