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oai:repisalud.isciii.es:20.500.12105/204462024-11-28T19:46:37Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Piotto, Stefano author Concilio, Simona author Sessa, Lucia author Diana, Rosita author Torrens, Gabriel author Juan, Carlos author Caruso, Ugo author Iannelli, Pio author 2017-08 Some novel (phenyl-diazenyl) phenols (4a-m) were designed and synthesized to be evaluated for their antibacterial activity. Starting from an active previously-synthesized azobenzene chosen as lead compound, we introduced some modifications and optimization of the structure, in order to improve solubility and drug conveyance. Structures of all newly-synthesized compounds were confirmed by H-1 nuclear magnetic resonance (NMR), mass spectrometry, and UV-Vis spectroscopy. Antibacterial activity of the new compounds was tested with the dilution method against the bacteria strains Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa PAO1. All the compounds were selectively active against Gram-positive bacteria. In particular, compounds 4d, 4h, and 4i showed the highest activity against S. aureus and Listeria monocytogenes, reaching remarkable MIC100 values of 4 mu g/mL and 8 mu g/mL. The relationship between antimicrobial activity and compound structure has suggested that the presence of hydroxyl groups seems to be essential for antimicrobial activity of phenolic compounds. Piotto S, Concilio S, Sessa L, Diana R, Torrens Ribot G, Juan C, et al. Synthesis and Antimicrobial Studies of New Antibacterial Azo-Compounds Active against Staphylococcus aureus and Listeria monocytogenes. Molecules. 2017 Aug;22(8):1372. 10.3390/molecules22081372 1420-3049 Molecules http://hdl.handle.net/20.500.13003/9708 28825625 L621990928 2-s2.0-85028002773 http://hdl.handle.net/20.500.12105/20446 408602900135 Azo-compound Gram-positive antibacterial Listeria monocytogenes Synthesis Synthesis and Antimicrobial Studies of New Antibacterial Azo-Compounds Active against Staphylococcus aureus and Listeria monocytogenes