2026-04-29T12:24:04Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/204272024-11-29T02:38:33Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Farooqi, Ammad Ahmad author Fayyaz, Sundas author Sanches Silva, Ana author Soldevila Verdeguer, Carla author Nabavi, Seyed Fazel author Mocan, Andrei author Nabavi, Seyed Mohammad author Bishayee, Anupam author 2017-05 Cancer comprises a collection of related diseases characterized by the existence of altered cellular pathways resulting in an abnormal tendency for uncontrolled growth. A broad spectrum, coordinated, and personalized approach focused on targeting diverse oncogenic pathways with low toxicity and economic natural compounds can provide a real benefit as a chemopreventive and/or treatment of this complex disease. Oleuropein, a bioactive phenolic compound mainly present in olive oil and other natural sources, has been reported to modulate several oncogenic signalling pathways. This review presents and critically discusses the available literature about the anticancer and onco-suppressive activity of oleuropein and the underlying molecular mechanisms implicated in the anticarcinogenic and therapeutic effects. The existence of limitations and the promising perspectives of research on this phenolic compound are also critically analyzed and discussed. Farooqi Ammad A, Fayyaz S, Sanches Silva A, Sureda Gomila A, Nabavi Seyed F, Mocan A, et al. Oleuropein and Cancer Chemoprevention: The Link is Hot. Molecules. 2017 May;22(5):705. 10.3390/molecules22050705 1420-3049 Molecules http://hdl.handle.net/20.500.13003/9839 28468276 L617825666 2-s2.0-85020222655 http://hdl.handle.net/20.500.12105/20427 404522900028 Cancer Chemopreventive effect Oleuropein Olive oil Oleuropein and Cancer Chemoprevention: The Link is Hot