2026-07-21T14:05:54Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/204252024-11-29T06:41:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Daglia, Maria author Di Lorenzo, Arianna author Nabavi, Seyed Fazel author Soldevila Verdeguer, Carla author Khanjani, Sedigheh author Moghaddam, Akbar Hajizadeh author Braidy, Nady author Nabavi, Seyed Mohammad 2024-07-11T09:07:46Z 2024-07-11T09:07:46Z 2017-05 Daglia M, Di Lorenzo A, Nabavi Seyed F, Sureda Gomila A, Khanjani S, Moghaddam Akbar H, et al. Improvement of Antioxidant Defences and Mood Status by Oral GABA Tea Administration in a Mouse Model of Post-Stroke Depression. Nutrients. 2017 May;9(5):446. 10.3390/nu9050446 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/9841 28468264 L615957251 2-s2.0-85019049903 http://hdl.handle.net/20.500.12105/20425 402054500024 Green GABA (GGABA) and Oolong GABA (OGABA) teas are relatively new varieties of tea, whose chemical composition and functional properties are largely under-studied, despite their promising health capacities. Post stroke depression (PSD) is a complication of stroke with high clinical relevance, yielding increasing mortality and morbidity rates, and a lower response to common therapies and rehabilitation. Methods: Two chemically characterized commercial samples of GGABA and OGABA were investigated for effects on mood following oral administration using a mouse model of PSD, through common validated tests including the Despair Swimming Test and Tail Suspension Test. Moreover, the antioxidant activity of GGABA and OGABA was evaluated by determining the levels of lipid peroxidation products and the activity of antioxidant enzymes in the mouse brain in vivo. Results: GGABA and OGABA attenuated depressed mood by influencing behavioral parameters linked to depression. GGABA was more active than OGABA in this study, and this effect may be likely due to a higher content of polyphenolic substances and amino acids in GGABA compared to OGABA. GGABA also exerted a greater antioxidant activity. Conclusions: Our data suggests that GABA tea is a promising candidate that can be used as an adjuvant in the management of PSD. eng GABA green tea GABA oolong tea Post-stroke depression Antioxidant activity Improvement of Antioxidant Defences and Mood Status by Oral GABA Tea Administration in a Mouse Model of Post-Stroke Depression research article