2026-07-23T17:12:33Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/204192024-11-29T02:39:17Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Ramos-Miguel, Alfredo author Garcia-Sevilla, Jesus A author Barr, Alasdair M author Bayer, Thomas A author Falkai, Peter author Leurgans, Sue E author Schneider, Julie A author Bennett, David A author Honer, William G author Julia Garcia-Fuster, M author 2017-03-20 Background: FADD (Fas-associated death domain) adaptor is a crucial protein involved in the induction of cell death but also mediates non-apoptotic actions via a phosphorylated form (p-Ser194-FADD). This study investigated the possible association of FADD forms with age-related neuropathologies, cognitive function, and the odds of dementia in an elderly community sample. Methods: FADD forms were quantified by western blot analysis in dorsolateral prefrontal cortex (DLPFC) samples from a large cohort of participants in a community-based aging study (Memory and Aging Project, MAP), experiencing no-(NCI, n = 51) or mild-(MCI, n = 42) cognitive impairment, or dementia (n = 57). Results: Cortical FADD was lower in subjects with dementia and lower FADD was associated with a greater load of amyloid-beta pathology, fewer presynaptic terminal markers, poorer cognitive function and increased odds of dementia. Together with the observations of FADD redistribution into tangles and dystrophic neurites within plaques in Alzheimer's disease brains, and its reduction in APP23 mouse cortex, the results suggest this multifunctional protein might participate in the mechanisms linking amyloid and tau pathologies during the course of the illness. Conclusions: The present data suggests FADD as a putative biomarker for pathological processes associated with the course of clinical dementia. Ramos-Miguel A, Garcia Sevilla JA, Barr Alasdair M, Bayer TA, Falkai P, Leurgans SE, et al. Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample. Mol Neurodegener. 2017 Mar 20;12:26. 10.1186/s13024-017-0168-x 1750-1326 Molecular Neurodegeneration http://hdl.handle.net/20.500.13003/9901 28320441 L614884738 2-s2.0-85015897461 http://hdl.handle.net/20.500.12105/20419 396648900001 Alzheimer's disease Aging Neurotoxicity Neuroplasticity Apoptosis Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample