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00925njm 22002777a 4500 dc Sharifi-Rad, Javad author Soldevila Verdeguer, Carla author Tenore, Gian Carlo author Daglia, Maria author Sharifi-Rad, Mehdi author Valussi, Marco author Tundis, Rosa author Sharifi-Rad, Marzieh author Loizzo, Monica R author Ademiluyi, Adedayo Oluwaseun author Sharifi-Rad, Razieh author Ayatollahi, Seyed Abdulmajid author Iriti, Marcello author 2017-01 Essential oils are complex mixtures of hydrocarbons and their oxygenated derivatives arising from two different isoprenoid pathways. Essential oils are produced by glandular trichomes and other secretory structures, specialized secretory tissues mainly diffused onto the surface of plant organs, particularly flowers and leaves, thus exerting a pivotal ecological role in plant. In addition, essential oils have been used, since ancient times, in many different traditional healing systems all over the world, because of their biological activities. Many preclinical studies have documented antimicrobial, antioxidant, anti-inflammatory and anticancer activities of essential oils in a number of cell and animal models, also elucidating their mechanism of action and pharmacological targets, though the paucity of in human studies limits the potential of essential oils as effective and safe phytotherapeutic agents. More well-designed clinical trials are needed in order to ascertain the real efficacy and safety of these plant products. Sharifi-Rad J, Sureda Gomila A, Tenore G, Daglia M, Sharifi-Rad M, Valussi M, et al. Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems. Molecules. 2017 Jan;22(1):70. 10.3390/molecules22010070 1420-3049 Molecules http://hdl.handle.net/20.500.13003/10004 28045446 L616198984 2-s2.0-85009458346 http://hdl.handle.net/20.500.12105/20399 395473500070 Isoprenoids Monoterpenes Antimicrobial activity Oral healthcare Traditional healing systems Ethnobotany Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems