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oai:repisalud.isciii.es:20.500.12105/203862024-11-29T06:18:15Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud author Gallardo, David author Bosch-Vizcaya, Anna author Rodriguez-Romanos, Rocio author Santos, Nazly author Buno, Ismael author de la Cámara, Rafael author Brunet, Salut author Jimenez-Velasco, Antonio author Gonzalez, Marcos author Nieto, Jose B author Martinez-Laperche, Carolina author Vallejo, Carlos author Ferra, Christelle author Sampol Mayol, Antonia author Lopez-Jimenez, Javier author Perez-Simon, Jose A author Martinez, Carmen author Diez, Jose-Luis author Spanish Hematopoietic Transplant 2024-07-11T09:07:22Z 2024-07-11T09:07:22Z 2017-12 Gallardo D, Bosch-Vizcaya A, Rodriguez-Romanos R, Santos N, Buno I, De la Camara R, et al. Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches. Biol Blood Marrow Transplant. 2017 Dec;23(12):2042-7. Epub 2017 Aug 4. 10.1016/j.bbmt.2017.08.003 1523-6536 1083-8791 Biology of Blood and Marrow Transplantation http://hdl.handle.net/20.500.13003/17289 28827064 L618107562 2-s2.0-85028624003 http://hdl.handle.net/20.500.12105/20386 418309000005 Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of acute GVHD. We explored the effect of the donor's CTLA-4 genotype in the incidence of acute GVHD associated with HA-1, HA-8, or H-Y miHA mismatches in a large cohort of 1295 patients receiving an allogeneic transplant from an HLA-identical sibling donor. The incidence of acute GVHD was higher if the donor and recipient were mismatched for HA-1, HA-8, or H-Y, but only when the donor had the CTLA-4 rs231775 AA genotype (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.75; P=.005; HR, 2.11, 95% CI, 1.06 to 4.18; P=.033; and HR, 1.50; 95% CI, 1.05 to 2.15; P=.025, respectively). In contrast, this increased risk of developing acute GVHD was not found when the donor presented the CTLA-4 rs231775 AG or GG genotypes. We conclude that the immune response to specific miHA mismatches is modulated by the CTLA-4 genotype of the donor. eng CTLA-4 Minor histocompatibility antigens Graft-versus-host disease Allogeneic transplantation Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches research article