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oai:repisalud.isciii.es:20.500.12105/203792024-11-29T00:04:40Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16980col_20.500.12105_16972

00925njm 22002777a 4500 dc Serrano Pariente, José author Plaza, V author Soriano, Joan B author Mayos, M author Lopez-Vina, A author Picado, C author Vigil, L author CPASMA Trial Grp author 2017-05 BackgroundContinuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies. MethodsProspective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index 20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention-to-treat basis. ResultsThe mean SD score of the ACQ decreased from 1.39 +/- 0.91 at baseline to 1.0 +/- 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4% to 17.2% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4% to 17.2% (P = 0.015). The score of the mAQLQ increased from 5.12 +/- 1.38 to 5.63 +/- 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P < 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients' weight. ConclusionsAsthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome. Serrano-Pariente J, Plaza V, Soriano JB, Mayos M, Lopez-Vina A, Picado C, et al. Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea. Allergy. 2017 May;72(5):802-12. Epub 2016 Nov 3. 10.1111/all.13070 1398-9995 0105-4538 Allergy http://hdl.handle.net/20.500.13003/17172 27732758 L613410808 2-s2.0-84996836542 http://hdl.handle.net/20.500.12105/20379 398734600014 Asthma Bronchial hyperreactivity Continuous positive airway pressure Obstructive sleep apnea syndrome Quality of life Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea