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oai:repisalud.isciii.es:20.500.12105/203712025-04-24T12:46:01Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16968

00925njm 22002777a 4500 dc Maurel, Marine author Mazagatos, Clara author Goerlitz, Luise author Oroszi, Beatrix author Hooiveld, Mariëtte author Machado, Ausenda author Domegan, Lisa author Ilić, Maja author Popescu, Rodica author Sève, Noémie author Martínez-Baz, Iván author Larrauri, Amparo author Buda, Silke author Túri, Gergő author Meijer, Adam author Gomez, Verónica author O'Donnell, Joan author Mlinarić, Ivan author Timnea, Olivia author Diez, Ana Ordax author Dürrwald, Ralf author Horváth, Judit Krisztina author Dijkstra, Frederika author Rodrigues, Ana Paula author McKenna, Adele author Filipović, Sanja Kurečić author Lazar, Mihaela author Kaczmarek, Marlena author Bacci, Sabrina author Kissling, Esther author VEBIS study team author 2024-06-11 Background: Within influenza vaccine effectiveness (VE) studies at primary care level with a laboratory-confirmed outcome, clinical case definitions for recruitment of patients can vary. We used the 2022-23 VEBIS primary care European multicentre study end-of-season data to evaluate whether the clinical case definition affected IVE estimates. Methods: We estimated VE using a multicentre test-negative case-control design. We measured VE against any influenza and influenza (sub)types, by age group (0-14, 15-64, ≥65 years) and by influenza vaccine target group, using logistic regression. We estimated IVE among patients meeting the European Union (EU) acute respiratory infection (ARI) case definition and among those meeting the EU influenza-like illness (ILI) case definition, including only sites providing information on specific symptoms and recruiting patients using an ARI case definition (as the EU ILI case definition is a subset of the EU ARI one). Results: We included 24 319 patients meeting the EU ARI case definition, of whom 21 804 patients (90 %) meet the EU ILI case definition, for the overall pooled VE analysis against any influenza. The overall and influenza (sub)type-specific VE varied by ≤2 % between EU ILI and EU ARI populations. Discussion: Among all analyses, we found similar VE estimates between the EU ILI and EU ARI populations, with few (10%) additional non-ILI ARI patients recruited. These results indicate that VE in the 2022-23 influenza season was not affected by use of a different clinical case definition for recruitment, although we recommend investigating whether this holds true for next seasons. Vaccine. 2024 Jun 11;42(16):3547-3554. http://hdl.handle.net/20.500.12105/20371 38704257 10.1016/j.vaccine.2024.04.060 1873-2518 Vaccine Influenza Influenza vaccine Vaccine effectiveness Clinical case definition Multicenter study Test-negative design Exploring the effect of clinical case definitions on influenza vaccine effectiveness estimation at primary care level: Results from the end-of-season 2022-23 VEBIS multicentre study in Europe