2026-06-14T03:45:18Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/203212024-09-21T13:39:12Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Cicuéndez, Beatriz
author
Pérez-García, Javier
author
Folgueira, Cintia
funder
Fundación La Caixa
funder
Novo Nordisk Foundation
funder
Fundación Lilly
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2024-07-09T10:23:18Z
2024-07-09T10:23:18Z
2024-01-31
Nutrients. 2024 Jan 31;16(3):424.
10.3390/nu16030424
2072-6643
Nutrients
38337707
http://hdl.handle.net/20.500.12105/20321
As the global obesity rate increases, so does the urgency to find effective anti-obesity drugs. In the search for therapeutic targets, central nervous system (CNS) mechanisms engaged in the regulation of energy expenditure and food intake, such as the opioid and dopamine systems, are crucial. In this study, we examined the effect on body weight of two drugs: bromocriptine (BC), a D2R receptor agonist, and PF-04455242, a selective κ opioid receptor (KOR) antagonist. Using diet-induced obese (DIO) rats, we aimed to ascertain whether the administration of BC and PF-04455242, independently or in combination, could enhance body weight loss. Furthermore, the present work demonstrates that the peripheral coadministration of BC and PF-04455242 enhances the reduction of weight in DIO rats and leads to a decrease in adiposity in a food-intake-independent manner. These effects were based on heightened energy expenditure, particularly through the activation of brown adipose tissue (BAT) thermogenesis. Overall, our findings indicate that the combination of BC and PF-04455242 effectively induces body weight loss through increased energy expenditure by increasing thermogenic activity and highlight the importance of the combined use of drugs to combat obesity.
eng
A Combination of a Dopamine Receptor 2 Agonist and a Kappa Opioid Receptor Antagonist Synergistically Reduces Weight in Diet-Induced Obese Rodents.
journal article
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URL
https://repisalud.isciii.es/bitstreams/ef4adef7-871e-49ac-a66e-8142934a7d18/download
File
MD5
dc11b2eeed496595c35f93c8c0465ffe
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application/pdf
A Combination of a Dopamine Receptor_Nutrients_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/873e8b5e-a4d9-409b-92d3-88f80a2647a7/download
File
MD5
99e4ed191a1f0a4d6a9e034b0d96f500
51816
text/plain
A Combination of a Dopamine Receptor_Nutrients_2024.pdf.txt