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Repisalud author Aparicio, J author Terrasa, J author Duran, Ignacio author Germa-Lluch, JR author Girones, R author Gonzalez-Billalabeitia, E author Guma, J author Maroto, P author Pinto, A author Garcia-del-Muro, X 2024-07-09T09:14:39Z 2024-07-09T09:14:39Z 2016-12 Aparicio J., Terrasa Pons Josefa, Duran I., Germa-Lluch J. R., Girones R., Gonzalez-Billalabeitia E., et al. SEOM clinical guidelines for the management of germ cell testicular cancer (2016). Clin Transl Oncol. 2016 Dec;18(12):1187-1196. Epub 2016 Nov 4. 1699-048X http://hdl.handle.net/20.500.13003/10064 http://hdl.handle.net/20.500.12105/20317 27815687 10.1007/s12094-016-1566-1 1699-3055 Clinical & Translational Oncology 2-s2.0-84994268334 389970300005 L613131025 Testicular cancer represents the most common malignancy in males aged 15-34 years and is considered a model of curable neoplasm. Maintaining success, reducing treatment burden, and focusing on survivorship are then key objectives. Inguinal orchiectomy is the first recommended maneuver that has both diagnostic and therapeutic aims. Most patients are diagnosed with stage I disease (confined to the testicle). Close surveillance and selective, short-course adjuvant chemotherapy are accepted alternatives for these cases. In patients with more advanced disease (stages II and III), 3-4 courses of cisplatin-based chemotherapy (according to IGCCCG risk classification) followed by the judicious surgical removal of residual masses represent the cornerstone of therapy. Poor-risk patients and those failing a first-line therapy should be referred to specialized tertiary centers. Paclitaxel-based conventional chemotherapy and high-dose chemotherapy plus autologous hematopoietic support can cure a proportion of patients with relapsing or refractory disease. eng Testicular cancer Germ-cell tumor Chemotherapy Surgery SEOM clinical guidelines for the management of germ cell testicular cancer (2016) research article