2026-06-14T02:28:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/203152024-11-28T15:51:48Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16938col_20.500.12105_16967col_20.500.12105_16983
Repisalud
author
Baena-Diez, Jose Miguel
author
Penafiel, Judit
author
Subirana, Isaac
author
Ramos-Asensio, Rafael
author
Elosua, Roberto
author
Marin-Ibanez, Alejandro
author
Guembe, Maria Jesus
author
Reigada Mendez, Rebeca
author
Tormo-Diaz, Maria Jose
author
Moreno-Iribas, Conchi
author
Cabre, Joan Josep
author
Segura, Antonio
author
Garcia-Lareo, Manel
author
Gomez de la Carnara, Agustin
author
Lapetra, Jose
author
Quesada, Miguel
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Marrugat, Jaume
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Medrano, Maria Jose
author
Berjon, Jesus
author
Frontera-Juan, Guillem
author
Gavrila, Diana
author
Barricarte, Aurelio
author
Basora, Josep
author
Garcia, Jose Maria
author
Pavone, Natalia C
author
Lora-Pablos, David
author
Mayora, Eduardo
author
Franch, Josep
author
Mata, Manel
author
Castell, Conxa
author
Frances, Albert
author
Grau, Maria
author
FRESCO Investigators
2024-07-09T09:14:38Z
2024-07-09T09:14:38Z
2016-11
Miguel Baena-Diez Jose, Penafiel Judit, Subirana Isaac, Ramos Rafel, Elosua Roberto, Marin-Ibanez Alejandro, et al. Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis. Diabetes Care. 2016 Nov;39(11):1987-1995. Epub 2016 Aug 4.
10.2337/dc16-0614
1935-5548
0149-5992
Diabetes Care
http://hdl.handle.net/20.500.13003/10113
27493134
L613125679
2-s2.0-84994300380
http://hdl.handle.net/20.500.12105/20315
386328800030
OBJECTIVE: Diabetes is a common cause of shortened life expectancy. We aimed to assess the association between diabetes and cause-specific death. RESEARCH DESIGN AND METHODS: We used the pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79 years old. Diabetes status was self-reported or defined as glycemia >125 mg/dL at baseline. Vital status and causes of death were ascertained by medical records review and linkage with the official death registry. The hazard ratios and cumulative mortality function were assessed with two approaches, with and without competing risks: proportional subdistribution hazard (PSH) and cause-specific hazard (CSH), respectively. Multivariate analyses were fitted for cardiovascular, cancer, and noncardiovascular noncancer deaths. RESULTS: We included 55,292 individuals (15.6% with diabetes and overall mortality of 9.1%). The adjusted hazard ratios showed that diabetes increased mortality risk: 1) cardiovascular death, CSH = 2.03 (95% CI 1.63-2.52) and PSH = 1.99 (1.60-2.49) in men; and CSH = 2.28 (1.75-2.97) and PSH = 2.23 (1.70-2.91) in women; 2) cancer death, CSH = 1.37 (1.13-1.67) and PSH = 1.35 (1.10-1.65) in men; and CSH = 1.68 (1.29-2.20) and PSH = 1.66 (1.25-2.19) in women; and 3) noncardiovascular non cancer death, CSH = 1.53 (1.23-1.91) and PSH = 1.50 (1.20-1.89) in men; and CSH = 1.89 (1.43-2.48) and PSH = 1.84 (1.39-2.45) in women. In all instances, the cumulative mortality function was significantly higher in individuals with diabetes. CONCLUSIONS: Diabetes is associated with premature death from cardiovascular disease, cancer, and noncardiovascular noncancer causes. The use of CSH and PSH provides a comprehensive view of mortality dynamics in a population with diabetes.
eng
Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis
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