2026-05-04T21:52:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/203142024-11-29T00:22:53Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16986
Repisalud
author
Barceló Bennasar, Antonia
author
Esquinas, Cristina
author
Robles, Juan
author
Pierola Lopetegui, Javier
author
de la Pena-Bravo, Monica
author
Aguilar, Irene
author
Morell Garcia, Danie
author
Alonso, Alberto
author
Toledo Pons, Nuria
author
Sanchez-de la Torre, Manuel
author
Barbe, Ferran
2024-07-09T09:14:37Z
2024-07-09T09:14:37Z
2016-10
Barcelo Bennasar Antonia, Esquinas Cristina, Robles Juan, Pierola Javier, De La Peña Bravo Mónica, Aguilar Irene, et al. Gut epithelial barrier markers in patients with obstructive sleep apnea. Sleep Med. 2016 Oct;26:12-15. Epub 2016 Sep 28.
10.1016/j.sleep.2016.01.019
1878-5506
1389-9457
Sleep Medicine
http://hdl.handle.net/20.500.13003/10169
28007354
L612928380
2-s2.0-84992740414
http://hdl.handle.net/20.500.12105/20314
390720900003
Background: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. Results: Compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables. Conclusions: The results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA.
eng
Zonulin
Fatty acid binding protein (I-FABP)
Intestinal wall
Sleep apnea
Gut epithelial barrier markers in patients with obstructive sleep apnea
research article