2026-05-04T21:52:27Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/203142024-11-29T00:22:53Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16986

00925njm 22002777a 4500 dc Barceló Bennasar, Antonia author Esquinas, Cristina author Robles, Juan author Pierola Lopetegui, Javier author de la Pena-Bravo, Monica author Aguilar, Irene author Morell Garcia, Danie author Alonso, Alberto author Toledo Pons, Nuria author Sanchez-de la Torre, Manuel author Barbe, Ferran author 2016-10 Background: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. Results: Compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables. Conclusions: The results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA. Barcelo Bennasar Antonia, Esquinas Cristina, Robles Juan, Pierola Javier, De La Peña Bravo Mónica, Aguilar Irene, et al. Gut epithelial barrier markers in patients with obstructive sleep apnea. Sleep Med. 2016 Oct;26:12-15. Epub 2016 Sep 28. 10.1016/j.sleep.2016.01.019 1878-5506 1389-9457 Sleep Medicine http://hdl.handle.net/20.500.13003/10169 28007354 L612928380 2-s2.0-84992740414 http://hdl.handle.net/20.500.12105/20314 390720900003 Zonulin Fatty acid binding protein (I-FABP) Intestinal wall Sleep apnea Gut epithelial barrier markers in patients with obstructive sleep apnea