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oai:repisalud.isciii.es:20.500.12105/203132024-11-29T02:52:54Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Tyrovolas, Stefanos author Haro, Josep Maria author Mariolis, Anargiros author Piscopo, Suzanne author Valacchi, Giuseppe author Bountziouka, Vassiliki author Anastasiou, Foteini author Zeimbekis, Akis author Tyrovola, Dimitra author Foscolou, Alexandra author Gotsis, Efthimios author Metallinos, George author Tur, Josep A author Matalas, Antonia author Lionis, Christos author Polychronopoulos, Evangelos author Panagiotakos, Demosthenes author 2016-09 Background: The determinants that promote successful ageing still remain unknown. The aim of the present work was to evaluate the role of skeletal muscle mass and body fat percentage (BF%), in the level of successful ageing. Methods: during 2005-2011, 2663 older (aged 65-100 years) from 21 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece were voluntarily enrolled in the study. Appendicular skeletal muscle mass (ASM), skeletal muscle mass index (SMI) and BF% were calculated using population formulas. Dietary habits, energy intake, expenditure and energy balance were derived throughout standard procedures. A successful ageing index ranging from 0 to 10 was used. Results: The mean ASM mass was 24 +/- 6.0 kg, the SMI was 0.84 +/- 0.21 and the BF% was 44%. Females had lower SMI and higher BF% in comparison with males, respectively [(SMI: 0.66 +/- 0.09 vs. 1.03 +/- 0.11; BF%: 51% vs. 34%, (p < 0.001)]. High successful agers had better rates in ASM (p = 0.01), SMI (p < 0.001) and BF% (p < 0.001), compared with the medium and low successful ones. Changes in SMI [b-coefficient (95% CI): 2.14 (1.57 to 2.71)] were positively associated with successful ageing, while changes in BF% [b-coefficient (95% CI): -0.04 (-0.05 to -0.03)] were inversely associated with successful ageing. Results from sensitivity analysis showed that the effects of variations on body composition were consistent, less pronounced in the positive energy balance group and more pronounced among the oldest old. Conclusions: Body composition changes seem to be associated with lower quality of life in the older adults, as measured through successful ageing. Tyrovolas Stefanos, Haro Josep-Maria, Mariolis Anargiros, Piscopo Suzanne, Valacchi Giuseppe, Bountziouka Vassiliki, et al. Skeletal muscle mass and body fat in relation to successful ageing of older adults: The multi-national MEDIS study. Arch Gerontol Geriatr. 2016 Sep;66:95-101. Epub 2016 May 9. 10.1016/j.archger.2016.04.017 1872-6976 0167-4943 Archives of Gerontology and Geriatrics http://hdl.handle.net/20.500.13003/10216 27266673 L610588866 2-s2.0-84971633033 http://hdl.handle.net/20.500.12105/20313 381646000014 Successful ageing Appendicular skeletal muscle mass Body fat Energy balance Older adults Skeletal muscle mass and body fat in relation to successful ageing of older adults: The multi-national MEDIS study