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oai:repisalud.isciii.es:20.500.12105/203052024-07-09T09:14:33Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16980col_20.500.12105_16984

00925njm 22002777a 4500 dc Sancho, Jesus author Servera, Emilio author Jara-Palomares, Luis author Barrot, Emilia author Sanchez-Oro-Gomez, Raque author Gomez de Terreros, F Javier author Martin-Vicente, M Jesus author Utrabo, Isabel author Núñez, Belén author Binimelis Varella, Alicia author Sala, Ernest author Zamora, Enrique author Segrelles, Gonzalo author Ortega-Gonzalez, Angel author Masa, Fernando author 2016 Chronically critically ill patients often undergo prolonged mechanical ventilation. The role of noninvasive ventilation (NIV) during weaning of these patients remains unclear. The aim of this study was to determine the value of NIV and whether a parameter can predict the need for NIV in chronically critically ill patients during the weaning process. We conducted a prospective study that included chronically critically ill patients admitted to Spanish respiratory care units. The weaning method used consisted of progressive periods of spontaneous breathing trials. Patients were transferred to NIV when it proved impossible to increase the duration of spontaneous breathing trials beyond 18 h. 231 chronically critically ill patients were included in the study. 198 (85.71%) patients achieved weaning success (mean weaning time 25.45�16.71 days), of whom 40 (21.4%) needed NIV during the weaning process. The variable which predicted the need for NIV was arterial carbon dioxide tension at respiratory care unit admission (OR 1.08 (95% CI 1.01-1.15), p=0.013), with a cut-off point of 45.5 mmHg (sensitivity 0.76, specificity 0.67, positive predictive value 0.76, negative predictive value 0.97). NIV is a useful tool during weaning in chronically critically ill patients. Hypercapnia despite mechanical ventilation at respiratory care unit admission is the main predictor of the need for NIV during weaning. Sancho J, Servera E, Jara-Palomares L, Barrot E, Sanchez-Oro-Gomez R, Gomez De Terreros FJ, et al. Noninvasive ventilation during the weaning process in chronically critically ill patients.. ERJ Open Res. 2016;2(4). 2016 Oct. 10.1183/23120541.00061-2016 2312-0541 ERJ Open Research http://hdl.handle.net/20.500.13003/17545 28053973 L613135743 2-s2.0-85017428901 http://hdl.handle.net/20.500.12105/20305 Noninvasive ventilation during the weaning process in chronically critically ill patients.