2026-08-29T10:23:32Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/202922024-11-28T17:20:22Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16960col_20.500.12105_16967

00925njm 22002777a 4500 dc Gomez-Sanchez, Leticia author Garcia-Ortiz, Luis author Carmen Patino-Alonso, M author Recio-Rodriguez, Jose I author Rigo Carratala, Fernando author Marti, Ruth author Agudo-Conde, Cristina author Rodriguez-Sanchez, Emiliano author Maderuelo-Fernandez, Jose A author Ramos-Asensio, Rafael author Gomez-Marcos, Manuel A author MARK Grp author 2016-10-24 Background: The cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV) can reflect both central and peripheral arterial stiffness. Metabolic syndrome (MetS) and its components may increase arterial stiffness and the risk of cardiovascular diseases. However, the correlation of MetS and its components with arterial stiffness is still not clear. The primary aim of this study is thus the relationship using baPWV and CAVI in Caucasian adults with intermediate cardiovascular risk. The secondary aim is to analyze sex differences. Methods: This study analyzed 2351 subjects aged 35-74 years (mean, 61.4 +/- 7.7 years) comprising 61.7 % males and enrolled in the improving interMediAte Risk management (MARK) study. CAVI was measured using a VaSera VS-1500 (R) device, and baPWV was calculated using a validated equation. MetS was defined based on the Joint Scientific Statement National Cholesterol Education Program III. Waist circumference, blood pressure, fasting plasma glucose, and lipid profile were measured. Results: MetS was found in 51.9 % of the subjects. All MetS components except reduced HDL-cholesterol (p = 0.578) were associated with CAVI. High density lipoprotein cholesterol (p = 0.075) and waist circumference (p = 0.315) were associated with baPWV. The different MetS components that assess dyslipidemia using the stiffness measures show different associations according to patient sex. The high blood pressure component had a greater odds ratio (OR) for both baPWV >= 17.5 m/sec (OR = 6.90, 95 % CI 3.52-13.519) and CAVI >= 9 (OR = 2.20, 95 % CI 1.63-1.90). Conclusions: MetS and all its components (except HDL-cholesterol with baPWV and CAVI and WC with baPWV) were associated with baPWV and CAVI. However, there were sex differences in the association of MetS and its components with baPWV and CAVI. Data from this study suggest a greater association of CAVI and baPWV values with MetS components in males than in females and indicate greater arterial stiffness in the event of simultaneously elevated blood pressure, fasting plasma glucose, and waist circumference. Gomez-Sanchez L, Garcia-Ortiz L, Patino-Alonso MC, Recio-Rodriguez JI, Rigo Carratala F, Marti R, et al. Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial. Cardiovasc Diabetol. 2016 Oct 24;15:148. 10.1186/s12933-016-0465-7 1475-2840 Cardiovascular Diabetology http://hdl.handle.net/20.500.13003/10118 27776526 L612885984 2-s2.0-84992386138 http://hdl.handle.net/20.500.12105/20292 385976600001 Metabolic syndrome Brachial-ankle pulse wave velocity Cardio-ankle vascular index Arterial stiffness Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial