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oai:repisalud.isciii.es:20.500.12105/202902024-11-28T20:58:11Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Capó Fiol, Xavier author Martorell, Miquel author Soldevila Verdeguer, Carla author Riera-Oliver, Joan author Drobnic, Franchek author Tur, Josep A author Pons, Antoni author 2016-10 n-3-polyunsaturated fatty acids and polyphenols are potential key factors for the treatment and prevention of chronic inflammation associated to ageing and non-communicable diseases. The aim was to analyse effects of an almond and olive oil beverage enriched with alpha-tocopherol and docosahexaenoic, exercise and age on inflammatory plasma markers, and immune gene expression in peripheral blood mononuclear cells (PBMCs). Five young and five senior athletes who were supplemented for five weeks with a functional beverage performed a stress test under controlled conditions before and after beverage supplementation. Blood samples were taken immediately before and 1 h after each test. Plasma, erythrocytes and PBMCs were isolated. Beverage supplementation increased plasmatic Tumour Necrosis Factor alpha (TNF alpha) levels depending on age and exercise. Exercise increased plasma non esterified fatty acids (NEFAs), soluble Intercellular adhesion molecule 3 (sICAM3) and soluble L-selectin (sL-Selectin), and this increase was attenuated by the supplementation. Exercise increased PGE2 plasma levels in supplemented young and in senior placebo athletes. Exercise increased NFk beta-activated levels in PBMCs, which are primed to a pro-inflammatory response increasing pro-inflammatory genes expression after the exercise mainly in the young group after the supplementation. The functional beverage supplementation to young athletes enhances a pro-inflammatory circulating environment in response to the exercise that was less evident in the senior group. Capo Fiol X, Martorell M, Sureda Gomila A, Riera J, Drobnic F, Tur J, et al. Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age. Nutrients. 2016 Oct;8(10):619. 10.3390/nu8100619 2072-6643 Nutrients http://hdl.handle.net/20.500.13003/10171 27735833 L612596308 2-s2.0-84991051904 http://hdl.handle.net/20.500.12105/20290 388665300037 Inflammation Docosahexaenoic acid Cytokines Physical performance Polyphenol Vitamin E Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age