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oai:repisalud.isciii.es:20.500.12105/202792024-11-28T19:34:50Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Lopez-Andrade, Bernardo author Gutierrez, Antonio author Garcia, Lucia author Cunill, Vanesa author Duran Pastor, Maria Antonia author Sampol Mayol, Antonia author Bernues, Marta author Iglesias, Julio author Ramos-Asensio, Rafael author Llado, Josep author Sanchez, Maria author Carlos Amat, Juan author Martinez-Serra, Jordi author 2016-07-29 B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph') is a neoplasm of lymphoblast committed to the B cell lineage. The clinical presentation of B-ALL Ph'+ is similar to B-ALL, but is more common in adults than in children. The e1a3 rare variant is produced by the fusion of BCR exon 1 to ABL exon 3. The presence of this translocation has been associated with good disease outcome for chronic myeloid leukemia in a very small series of only 5 cases; there is no such evidence for B-ALL. We report two new cases of B-ALL Ph+ with the rare e1a3 fusion transcript. The e1a3 and e1a2 (p190) transcripts have been reported to have a similar molecular weight and probably a similar clinical profile, thus in these cases the presence of e1a3 was associated with extramedullary infiltration and disease acceleration. Lopez-Andrade B, Sartori F, Gutierrez A, Garcia L, Cunill Monjo V, Duran Pastor MA, et al. Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases. Exp Hematol Oncol. 2016 Jul 29;5:21. 10.1186/s40164-016-0049-y 2162-3619 Experimental Hematology & Oncology http://hdl.handle.net/20.500.13003/10270 27478684 L611406479 2-s2.0-85006219363 http://hdl.handle.net/20.500.12105/20279 381118900001 Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases