2026-05-04T21:52:32Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/202752024-11-28T23:35:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16986
Repisalud
author
Sanchez-de-la-Torre, Alicia
author
Abad, Jorge
author
Duran Cantolla, Joaquin
author
Mediano San Andres, Olga
author
Cabriada, Valentin
author
Jose Masdeu, Maria
author
Teran, Joaquin
author
Fernando Masa, Juan
author
de la Pena-Bravo, Monica
author
Aldoma, Albina
author
Worner, Fernando
author
Valls, Joan
author
Barbe, Ferran
author
Sanchez-de-la-Torre, Manuel
author
Spanish Sleep Grp
2024-07-09T09:14:06Z
2024-07-09T09:14:06Z
2016-07-14
Sanchez-De-La-Torre A, Abad J, Duran-Cantolla J, Mediano O, Cabriada V, Masdeu MJ, et al. Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome. PLoS One. 2016 Jul 14;11(7):e0159207.
10.1371/journal.pone.0159207
1932-6203
PloS One
http://hdl.handle.net/20.500.13003/10277
27416494
L611245026
2-s2.0-84978544489
http://hdl.handle.net/20.500.12105/20275
379579500098
Background: The cardiovascular consequences of obstructive sleep apnoea (OSA) differ by sex. We hypothesized that sex influences the severity of acute coronary syndrome (ACS) in patients with OSA. OSA was defined as an apnoea-hypopnoea index (AHI)>15 events.h(-1). We evaluated the severity of ACS according to the ejection fraction, Killip class, number of diseased vessels, number of stents implanted and plasma peak troponin level. Methods We included 663 men (mean +/- SD, AHI 37 +/- 18 events.h(-1)) and 133 women (AHI 35 +/- 18 events.h(-1)) with OSA. Results: The men were younger than the women (59 +/- 11 versus 66 +/- 11 years, p<0.0001), exhibited a higher neck circumference (p<0.0001), and were more likely to be smokers and alcohol users than women (p<0.0001, p = 0.0005, respectively). Body mass index and percentage of hypertensive patients or diabetics were similar between sexes. We observed a slight tendency for a higher Killip classification in women, although it was not statistically significant (p = 0.055). For men, we observed that the number of diseased vessels and the number of stents implanted were higher (p = 0.02, p = 0.001, respectively), and a decrease in the ejection fraction (p = 0.002). Conclusions: This study shows that sex in OSA influences the severity of ACS. Men show a lower ejection fraction and an increased number of diseased vessels and number of stents implanted.
eng
Effect of Patient Sex on the Severity of Coronary Artery Disease in Patients with Newly Diagnosis of Obstructive Sleep Apnoea Admitted by an Acute Coronary Syndrome
research article