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00925njm 22002777a 4500 dc Lassale, Camille author Gunter, Marc J author Romaguera, Dora author Peelen, Linda M author Van der Schouw, Yvonne T author Beulens, Joline WJ author Freisling, Heinz author Muller, David C author Ferrari, Pietro author Huybrechts, Inge author Fagherazzi, Guy author Boutron-Ruault, Marie-Christine author Affret, Aurelie author Overvad, Kim author Dahm, Christina Catherine author Olsen, Anja author Roswall, Nina author Tsilidis, Konstantinos K author Katzke, Verena A author Kuehn, Tilman author Buijsse, Brian author Quiros, Jose-Ramon author Sanchez-Cantalejo, Emilio author Etxezarreta, Nerea author Huerta, José María author Barricarte, Aurelio author Bonet, Catalina author Khaw, Kay-Tee author Key, Timothy J author Trichopoulou, Antonia author Bamia, Christina author Lagiou, Pagona author Palli, Domenico author Agnoli, Claudia author Tumino, Rosario author Fasanelli, Francesca author Panico, Salvatore author Bueno-de-Mesquita, H. Bas author Boer, Jolanda M. A author Sonestedt, Emily author Nilsson, Lena Maria author Renstrom, Frida author Weiderpass, Elisabete author Skeie, Guri author Lund, Eiliv author Moons, Karel G. M author Riboli, Elio author Tzoulaki, Ioanna author 2016-07-13 Scores of overall diet quality have received increasing attention in relation to disease aetiology; however, their value in risk prediction has been little examined. The objective was to assess and compare the association and predictive performance of 10 diet quality scores on 10-year risk of all-cause, CVD and cancer mortality in 451,256 healthy participants to the European Prospective Investigation into Cancer and Nutrition, followed-up for a median of 12.8y. All dietary scores studied showed significant inverse associations with all outcomes. The range of HRs (95% CI) in the top vs. lowest quartile of dietary scores in a composite model including non-invasive factors (age, sex, smoking, body mass index, education, physical activity and study centre) was 0.75 (0.72-0.79) to 0.88 (0.84-0.92) for all-cause, 0.76 (0.69-0.83) to 0.84 (0.76-0.92) for CVD and 0.78 (0.73-0.83) to 0.91 (0.85-0.97) for cancer mortality. Models with dietary scores alone showed low discrimination, but composite models also including age, sex and other non-invasive factors showed good discrimination and calibration, which varied little between different diet scores examined. Mean C-statistic of full models was 0.73, 0.80 and 0.71 for all-cause, CVD and cancer mortality. Dietary scores have poor predictive performance for 10-year mortality risk when used in isolation but display good predictive ability in combination with other non-invasive common risk factors. Lassale C, Gunter MJ, Romaguera D, Peelen LM, Van Der Schouw YT, Beulens Joline WJ, et al. Diet Quality Scores and Prediction of All-Cause, Cardiovascular and Cancer Mortality in a Pan-European Cohort Study. PLoS One. 2016 Jul 13;11(7):e0159025. 10.1371/journal.pone.0159025 1932-6203 PloS One http://hdl.handle.net/20.500.13003/10278 27409582 L611245413 2-s2.0-84978771288 http://hdl.handle.net/20.500.12105/20274 379508300050 Diet Quality Scores and Prediction of All-Cause, Cardiovascular and Cancer Mortality in a Pan-European Cohort Study