2026-06-30T03:49:37Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/202642024-11-28T22:03:27Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Bibiloni Esteva, Maria Del Mar author Salas, Rogelio author Nunez, Georgina M author Villarreal, Jesus Z author Soldevila Verdeguer, Carla author Tur, Josep A author 2016-05-20 Background and Aims: The increase in overweight and obese children may be linked to increased rates of liver damage and dyslipidaemia. This study aimed to explore the associations of liver biomarkers with overweight/obesity and dyslipidaemia in Mexican children. Methods: The study was a population-based cross-sectional nutritional survey carried out in the State of Nuevo Leon, Mexico. The study included a 414 subjects aged between 2 and 10 years old (47.8% girls) who took part in the State Survey of Nutrition and Health-Nuevo Leon 2011/2012. Associations between alanine aminotransferase (ALT) and aspartate aminotransferase (AST), ALT/AST ratio, and major components of serum lipid profile were assessed. Results: Children with high ALT (defined as >= P-75) showed higher prevalence of dyslipidaemia than their counterparts, with high prevalence of high TChol (P = 0.053), non-HDL-chol, TG, and low HDL-chol. Children with an AST/ALT >= T3 ratio were 0.43-times (95% CI: 0.25-0.74) and 0.27-times (95% CI: 0.17-0.44) low likely to be overweight/obese and to have dyslipidaemia than those with an AST/ALT <T1 ratio, respectively. The risk of high TChol, LDL-chol, non-HDL-chol and TG, and low HDL-chol levels also decreased in AST/ALT ratio groups. Conclusions: Our results pose the need for further investigation on whether AST/ALT may be useful as screening test in the assessment of children with cardiometabolic risk. Bibiloni Esteva MM, Salas R, Nunez GM, Villarreal JZ, Sureda Gomila A, Tur J. Relation between Liver Transaminases and Dyslipidaemia among 2-10 y.o. Northern Mexican Children. PLoS One. 2016 May 20;11(5):e0155994. 10.1371/journal.pone.0155994 1932-6203 PloS One http://hdl.handle.net/20.500.13003/10360 27203747 L610470876 2-s2.0-84991518885 http://hdl.handle.net/20.500.12105/20264 376291500038 Relation between Liver Transaminases and Dyslipidaemia among 2-10 y.o. Northern Mexican Children