2026-06-14T03:32:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/202572024-11-29T08:11:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Capó Fiol, Xavier
author
Martorell, M
author
Sureda Gomila, Antoni
author
Tur, Josep A
author
Pons, A
2024-07-09T09:13:13Z
2024-07-09T09:13:13Z
2016-04-05
Capo Fiol X, Martorell M, Sureda Gomila A, Tur J, Pons A. Effects of dietary Docosahexaenoic, training and acute exercise on lipid mediators. J Int Soc Sport Nutr. 2016 Apr 05;13:16.
10.1186/s12970-016-0126-y
1550-2783
Journal of the International Society of Sports Nutrition
http://hdl.handle.net/20.500.13003/10396
27051354
L616138862
2-s2.0-84962052395
http://hdl.handle.net/20.500.12105/20257
373426900001
Background: Eicosanoids mediate initiation and resolution of inflammation. Our aim was evaluating the effects of training, exercise and docosahexaenoic (DHA) supplementation on plasma eicosanoids levels and peripheral blood mononuclear cells (PBMCs) eicosanoids production. Methods: Fifteen male footballers were distributed to placebo and experimental groups. Experimental group consumed DHA-enriched beverage (1.16 g DHA/day) for 8 weeks, placebo group consumed a placebo beverage. Blood samples were taken before and after the nutritional intervention in basal conditions and 2 h after acute exercise. Results: Training increased basal Prostaglandin E1 (PGE(1)) plasma levels and PBMCs cyclooxygenase 2 (COX-2) protein levels in both groups, but COX-1 protein levels only in the experimental group. Acute exercise increased plasma PGE(2) and PBMCs active NF kappa beta levels. Lipopolysaccharide (LPS)-stimulated PBMCs increases eicosanoids production (PGE(1), PGE(2), RvD1) in both groups and increased LPS-stimulated PBMCs active NF kappa beta. DHA supplementation increased COX-2 levels but decreased LPS-stimulated PBMCs PGE(1) and PGE(2) production. Neither DHA supplementation nor acute exercise altered the expression of NF kappa beta, COX-2, 15-LOX2, 5-LOX, or IL-1 beta genes in PBMCs. Conclusions: The increase of PGE(1) plasma levels after training promoted systemic anti-inflammatory and vasodilator environment. Exercise and DHA supplementation acted synergistically by increasing plasma PGE(2) with anti-inflammatory effects. Exercise primed PBMCs to enhance PGE(1), PGE(2) and RvD1 production in response to LPS.
eng
Inflammation
Docosahexaenoic acid
PGE(1)
PGE(2)
RvD1
Lipid mediators
Exercise
Effects of dietary Docosahexaenoic, training and acute exercise on lipid mediators
research article