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oai:repisalud.isciii.es:20.500.12105/202572024-11-29T08:11:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Capó Fiol, Xavier author Martorell, M author Sureda Gomila, Antoni author Tur, Josep A author Pons, A author 2016-04-05 Background: Eicosanoids mediate initiation and resolution of inflammation. Our aim was evaluating the effects of training, exercise and docosahexaenoic (DHA) supplementation on plasma eicosanoids levels and peripheral blood mononuclear cells (PBMCs) eicosanoids production. Methods: Fifteen male footballers were distributed to placebo and experimental groups. Experimental group consumed DHA-enriched beverage (1.16 g DHA/day) for 8 weeks, placebo group consumed a placebo beverage. Blood samples were taken before and after the nutritional intervention in basal conditions and 2 h after acute exercise. Results: Training increased basal Prostaglandin E1 (PGE(1)) plasma levels and PBMCs cyclooxygenase 2 (COX-2) protein levels in both groups, but COX-1 protein levels only in the experimental group. Acute exercise increased plasma PGE(2) and PBMCs active NF kappa beta levels. Lipopolysaccharide (LPS)-stimulated PBMCs increases eicosanoids production (PGE(1), PGE(2), RvD1) in both groups and increased LPS-stimulated PBMCs active NF kappa beta. DHA supplementation increased COX-2 levels but decreased LPS-stimulated PBMCs PGE(1) and PGE(2) production. Neither DHA supplementation nor acute exercise altered the expression of NF kappa beta, COX-2, 15-LOX2, 5-LOX, or IL-1 beta genes in PBMCs. Conclusions: The increase of PGE(1) plasma levels after training promoted systemic anti-inflammatory and vasodilator environment. Exercise and DHA supplementation acted synergistically by increasing plasma PGE(2) with anti-inflammatory effects. Exercise primed PBMCs to enhance PGE(1), PGE(2) and RvD1 production in response to LPS. Capo Fiol X, Martorell M, Sureda Gomila A, Tur J, Pons A. Effects of dietary Docosahexaenoic, training and acute exercise on lipid mediators. J Int Soc Sport Nutr. 2016 Apr 05;13:16. 10.1186/s12970-016-0126-y 1550-2783 Journal of the International Society of Sports Nutrition http://hdl.handle.net/20.500.13003/10396 27051354 L616138862 2-s2.0-84962052395 http://hdl.handle.net/20.500.12105/20257 373426900001 Inflammation Docosahexaenoic acid PGE(1) PGE(2) RvD1 Lipid mediators Exercise Effects of dietary Docosahexaenoic, training and acute exercise on lipid mediators