2026-05-20T23:32:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/202542024-11-28T22:44:51Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Gomez-Florit, Manuel
author
Pacha-Olivenza, Miguel A
author
Fernandez-Calderon, Maria C
author
Cordoba, Alba
author
Gonzalez-Martin, Maria L
author
Monjo, Marta
author
Ramis, Joana Maria
2024-07-09T09:13:11Z
2024-07-09T09:13:11Z
2016-03-01
Gomez-Florit M, Pacha-Olivenza MA, Fernandez-Calderon MC, Cordoba A, Gonzalez-Martin ML, Monjo M, et al. Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria. Sci Rep. 2016 Mar 01;6:22444.
10.1038/srep22444
2045-2322
Scientific Reports
http://hdl.handle.net/20.500.13003/10447
26925553
L616507039
2-s2.0-84959567765
http://hdl.handle.net/20.500.12105/20254
371037000003
Many dental implants fail due to the infection and inflammation that walk hand in hand with poor healing and soft tissue integration. Titanium surfaces were nanocoated with quercitrin, a natural flavonoid, with the aim to improve soft tissue integration and increase dental implants success. Streptococcus mutans attachment and biofilm formation was analysed. Then, the anti-inflammatory properties and the potential of quercitrin-nanocoated surfaces to boost soft tissue regeneration were tested using human gingival fibroblasts. An inflammatory situation was mimicked using interleulin-1-beta. We found that quercitrin-nanocoated surfaces decreased initial bacterial adhesion while increasing human gingival fibroblasts attachment. Furthermore, quercitrin-nanocoated Ti increased collagen mRNA levels and decreased matrix metalloproteinase-1/tissue inhibitor of metalloproteinanse-1 mRNA ratio, which is related to a reduced metalloproteinase-mediated collagen degradation, while also decreasing the pro-inflammatory prostaglandin E-2 release under basal and inflammatory conditions. These results suggest that quercitrin-nanocoated surfaces could enhance the soft tissue integration and increase dental implants success.
eng
Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria
research article