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oai:repisalud.isciii.es:20.500.12105/202542024-11-28T22:44:51Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Gomez-Florit, Manuel author Pacha-Olivenza, Miguel A author Fernandez-Calderon, Maria C author Cordoba, Alba author Gonzalez-Martin, Maria L author Monjo, Marta author Ramis, Joana Maria author 2016-03-01 Many dental implants fail due to the infection and inflammation that walk hand in hand with poor healing and soft tissue integration. Titanium surfaces were nanocoated with quercitrin, a natural flavonoid, with the aim to improve soft tissue integration and increase dental implants success. Streptococcus mutans attachment and biofilm formation was analysed. Then, the anti-inflammatory properties and the potential of quercitrin-nanocoated surfaces to boost soft tissue regeneration were tested using human gingival fibroblasts. An inflammatory situation was mimicked using interleulin-1-beta. We found that quercitrin-nanocoated surfaces decreased initial bacterial adhesion while increasing human gingival fibroblasts attachment. Furthermore, quercitrin-nanocoated Ti increased collagen mRNA levels and decreased matrix metalloproteinase-1/tissue inhibitor of metalloproteinanse-1 mRNA ratio, which is related to a reduced metalloproteinase-mediated collagen degradation, while also decreasing the pro-inflammatory prostaglandin E-2 release under basal and inflammatory conditions. These results suggest that quercitrin-nanocoated surfaces could enhance the soft tissue integration and increase dental implants success. Gomez-Florit M, Pacha-Olivenza MA, Fernandez-Calderon MC, Cordoba A, Gonzalez-Martin ML, Monjo M, et al. Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria. Sci Rep. 2016 Mar 01;6:22444. 10.1038/srep22444 2045-2322 Scientific Reports http://hdl.handle.net/20.500.13003/10447 26925553 L616507039 2-s2.0-84959567765 http://hdl.handle.net/20.500.12105/20254 371037000003 Quercitrin-nanocoated titanium surfaces favour gingival cells against oral bacteria