2026-06-14T03:40:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/202452024-11-28T23:51:50Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Barceló, Pere
author
Nicolau Llobera, Maria Cristina
author
Gamundí, Antoni
author
Fiol-deRoque, Maria Antonia
author
Tresguerres, Jesus A. F
author
Akaârir, Mourad
author
Rial, Rubén V
2024-07-09T09:13:06Z
2024-07-09T09:13:06Z
2016
Barcelo P, Nicolau Llobera MC, Gamundi Gamundi A, Fiol Maria A, Tresguerres Jesus AF, Akaârir El Ghourri M, et al. Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats. Oxidative Med Cell Longev. 2016;2016:5863402. Epub 2016 Dec 5.
10.1155/2016/5863402
1942-0994
1942-0900
Oxidative Medicine and Cellular Longevity
http://hdl.handle.net/20.500.13003/10518
28050228
L613974670
2-s2.0-85009107890
http://hdl.handle.net/20.500.12105/20245
390564600001
Growth hormone (GH) and melatonin are two hormones with quite different physiological effects. Curiously, their secretion shows parallel and severe age-related reductions. This has promoted many reports for studying the therapeutic supplementation of both hormones in an attempt to avoid or delay the physical, physiological, and psychological decay observed in aged humans and in experimental animals. Interestingly, the effects of the external administration of low doses of GH and of melatonin were surprisingly similar, as both hormones caused significant improvements in the functional capabilities of aged subjects. The present report aims at discerning the eventual difference between cognitive and motor effects of the two hormones when administered to young and aged Wistar rats. The effects were tested in the radial maze, a test highly sensitive to the age-related impairments in working memory and also in the rotarod test, for evaluating the motor coordination. The results showed that both hormones caused clear improvements in both tasks. However, while GH improved the cognitive capacity and, most importantly, the physical stamina, the effects of melatonin should be attributed to its antioxidant, anxiolytic, and neuroprotective properties.
eng
Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats
research article