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oai:repisalud.isciii.es:20.500.12105/202392024-11-28T15:54:29Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16938col_20.500.12105_16967col_20.500.12105_16972

00925njm 22002777a 4500 dc Plaza, Vicente author Fernández-Rodríguez, Concepción author Melero, Carlos author García-Cosío, Borja author Manuel Entrenas, Luis author Perez de Llano, Luis Alejandro author Gutierrez-Pereyra, Fernando author Tarragona, Eduard author Palomino, Rosa author Lopez-Vina, Antolin author TAI Study Grp author 2016-04-01 Background: To validate the Test of Adherence to Inhalers' (TAI), a 12-item questionnaire designed to assess the adherence to inhalers in patients with COPD or asthma. Methods: A total of 1009 patients with asthma or COPD participated in a cross-sectional multicenter study. Patients with electronic adherence 80% were defined as adherents. Construct validity, internal validity, and criterion validity were evaluated. Self-reported adherence was compared with the Morisky-Green questionnaire. Results: Factor analysis study demonstrated two factors, factor 1 was coincident with TAI patient domain (items 1 to 10) and factor 2 with TAI health-care professional domain (items 11 and 12). The Cronbach's alpha was 0.860 and the test-retest reliability 0.883. TAI scores correlated with electronic adherence (=0.293, p=0.01). According to the best cut-off for 10 items (score 50, area under the ROC curve 0.7), 569 (62.5%) patients were classified as non-adherents. The non-adherence behavior pattern was: erratic 527 (57.9%), deliberate 375 (41.2%), and unwitting 242 (26.6%) patients. As compared to Morisky-Green test, TAI showed better psychometric properties. Conclusions: The TAI is a reliable and homogeneous questionnaire to identify easily non-adherence and to classify from a clinical perspective the barriers related to the use of inhalers in asthma and COPD. Plaza V, Fernandez-Rodriguez C, Melero C, Cosio BG, Entrenas LM, Perez De Llano L, et al. Validation of the 'Test of the Adherence to Inhalers' (TAI) for Asthma and COPD Patients. J Aerosol Med Pulm Drug Deliv. 2016 Apr 01;29(2):142-52. Epub 2015 Jul 31. 10.1089/jamp.2015.1212 1941-2703 1941-2711 Journal of Aerosol Medicine and Pulmonary Drug Delivery http://hdl.handle.net/20.500.13003/17304 26230150 L610199098 2-s2.0-84964762520 http://hdl.handle.net/20.500.12105/20239 373922800005 Anti-asthmatic agents Administration and dosage Inhalers Medication adherence Medication non-adherence Questionnaires Pulmonary disease Chronic obstructive Drug therapy Validation studies Validation of the 'Test of the Adherence to Inhalers' (TAI) for Asthma and COPD Patients