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oai:repisalud.isciii.es:20.500.12105/202372025-04-01T10:46:39Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16959col_20.500.12105_16967col_20.500.12105_16968col_20.500.12105_16981

00925njm 22002777a 4500 dc Larranaga, Nerea author Jose Sanchez, Ma author Ardanaz, Eva author Felipe, Saray author Marcos-Gragera, Rafael author Ramos Monserrat, Maria author Carulla, Maria author Chirlaque, María-Dolores author Argueelles, Marcial V author Martos, Carmen author Mateo, Antonio author Peris-Bonet, Rafael author 2016 Objective: To describe incidence patterns and trends in children (0-14 years) and adolescents (15-19 age-range) with solid tumours, except those of central nervous system (CNS), in Spain. Methods: Cases were drawn from eleven Spanish population-based cancer registries. Incidence was estimated for the period 1983-2007 and trends were evaluated using Joinpoint regression analysis. Results: The studied tumour groups accounted for 36% of total childhood cancers and 47.6% of those diagnosed in adolescence with annual rates per million of 53.5 and 89.3 respectively. In children 0 to 14 years of age, Neuroblastoma (NB) was the commonest (7.8%) followed by Soft-tissue sarcomas (STS) (6.3%), bone tumours (BT) (6.2%) and renal tumours (RT) (4.5%). NB was the most frequently diagnosed tumour before the 5th birthday, while STS and BT were the commonest at 5-9 years of age, and BT and Carcinoma and other epithelial tumours (COET) at 10-14. COET presented the highest incidence in adolescents, followed by germ-cell tumours (GCT), BT and STS. These four diagnostic groups accounted for 94% of total non-CNS solid tumours, in adolescents. Overall incidence rates increased significantly in children up to 1996 with an annual percentage change (APC) of 2.6% (95% CI: 1.7; 3.6). NB and COET showed significant time trend (APCs: 1.4% and 3.8% respectively) while other tumour groups such as RT, STS, BT or GCT had no significant changes over time. A significant increase was present in NB under the age of 5 and in BT and STS in children aged 10-14 years. In adolescents there were significant increases for all tumours combined (APC=2.7; 95% CI: 1.8-3.6) and for STS, GCT and COET (APCs: 3.2%, 4.4% and 3.5% respectively), while other tumour groups such as hepatic tumours, BT or thyroid carcinomas showed a decreasing trend or no increase. Conclusions: Overall, the incidence of the studied cancers in children increased along the period 1983-1996 with no posterior significant rise, while the incidence in adolescents increased significantly over the whole period 1983-2007. Several specific tumour groups showed significant rises or decrements in childhood or adolescence, although the small number of cases precludes showing significant trends or inflexion points. Larranaga N, Sanchez MJ, Ardanaz E, Felipe S, Marcos-Gragera R, Ramos Monserrat M, et al. Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries. J Cancer. 2016;7(3):335-43. 10.7150/jca.12943 1837-9664 Journal of Cancer http://hdl.handle.net/20.500.13003/17183 26918047 L610558667 2-s2.0-84971577855 http://hdl.handle.net/20.500.12105/20237 370178400014 Cancer Solid tumour Childhood Adolescents Population-based study Incidence Spain Incidence Patterns and Trends of non-Central Nervous System Solid Tumours in Children and Adolescents. A Collaborative Study of the Spanish Population Based Cancer Registries