2026-08-05T15:04:41Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/202342024-07-09T09:13:00Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967
Repisalud
author
Faner, Rosa
author
Sobradillo, Patricia
author
Noguera, Aina
author
Gómez Cobo, Cristina
author
Cruz, Tamara
author
Lopez-Giraldo, Alejandra
author
Ballester, Eugeni
author
Soler, Nestor
author
Arostegui, Juan I
author
Pelegrin, Pablo
author
Rodriguez-Roisin, Roberto
author
Yague, Jordi
author
García-Cosío, Borja
author
Juan, Manel
author
Agusti, Alvar
2024-07-09T09:13:00Z
2024-07-09T09:13:00Z
2016
Faner Rosa, Sobradillo P, Noguera A, Gomez C, Cruz T, Lopez-Giraldo A, et al. The inflammasome pathway in stable COPD and acute exacerbations. ERJ Open Res. 2016;2(3). 2016 Jul.
10.1183/23120541.00002-2016
2312-0541
ERJ Open Research
http://hdl.handle.net/20.500.13003/17225
27730204
L605345973
2-s2.0-84937720799
http://hdl.handle.net/20.500.12105/20234
Chronic obstructive pulmonary disease (COPD) is characterised by pulmonary and systemic inflammation that bursts during exacerbations of the disease (ECOPD). The NLRP3 inflammasome is a key regulatory molecule of the inflammatory response. Its role in COPD is unclear. We investigated the NLRP3 inflammasome status in: 1) lung tissue samples from 38 patients with stable COPD, 15 smokers with normal spirometry and 14 never-smokers; and 2) sputum and plasma samples from 56 ECOPD patients, of whom 41 could be reassessed at clinical recovery. We observed that: 1) in lung tissue samples of stable COPD patients, NLRP3 and interleukin (IL)-1beta mRNA were upregulated, but both caspase-1 and ASC were mostly in inactive form, and 2) during infectious ECOPD, caspase-1, oligomeric ASC and associated cytokines (IL-1beta, IL-18) were significantly increased in sputum compared with clinical recovery. The NLRP3 inflammasome is primed, but not activated, in the lungs of clinically stable COPD patients. Inflammasome activation occurs during infectious ECOPD. The results of this study suggest that the inflammasome participates in the inflammatory burst of infectious ECOPD.
eng
The inflammasome pathway in stable COPD and acute exacerbations.
research article