2026-08-29T16:26:19Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/202322024-11-28T22:33:00Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967col_20.500.12105_16983

00925njm 22002777a 4500 dc Bousquet, J author Anto, JM author Akdis, M author Auffray, C author Keil, T author Momas, I author Postma, DS author Valenta, R author Wickman, M author Cambon-Thomsen, A author Haahtela, Tari author Lambrecht, BN author Lodrup Carlsen, KC author Koppelman, G. H author Sunyer, J author Zuberbier, T author Annesi-Maesano, I author Arno, A author Bindslev-Jensen, C author De Carlo, G author Forastiere, Francesco author Heinrich, Joachim author Kowalski, ML author Maier, D author Melen, E author Palkonen, S author Smit, HA author Standl, M author Wright, J author Asarnoj, A author Benet, M author Ballardini, N author Garcia-Aymerich, J author Gehring, U author Guerra, S author Hohman, C author Kull, I author Lupinek, C author Pinart, M author Skrindo, I author Westman, M author Smagghe, D author Akdis, C author Albang, R author Anastasova, V author Anderson, N author Bachert, C author Ballereau, S author Ballester, F author Basagana, X author Bedbrook, A author Bergstrom, A author von Berg, A author Brunekreef, B author Burte, E author Carlsen, KH author Chatzi, L author Coquet, JM author Curin, M author Demoly, P author Eller, E author Fantini, Maria Pia author Gerhard, B author Hammad, H author von Hertzen, L author Hovland, V author Jacquemin, B author Just, J author Keller, T author Kerkhof, M author Kiss, R author Kogevinas, M author Koletzko, S author Lau, S author Lehmann, I author Lemonnier, N author McEachan, R author Makela, M author Mestres, J author Minina, E author Mowinckel, P author Nadif, R author Nawijn, M author Oddie, S author Pellet, J author Pin, I author Porta, D author Ranciere, F author Rial-Sebbag, A author Saeys, Y author Schuijs, MJ author Siroux, V author Tischer, CG author Torrent Quetglas, Maties author Varraso, R author De Vocht, J author Wenger, K author Wieser, S author Xu, C author 2016-11 MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda. Bousquet J, Anto JM, Akdis M, Auffray C, Keil T, Momas I, et al. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015. Allergy. 2016 Nov;71(11):1513-25. Epub 2016 Aug 23. 10.1111/all.12880 1398-9995 0105-4538 Allergy http://hdl.handle.net/20.500.13003/17179 26970340 L612654547 2-s2.0-84990872120 http://hdl.handle.net/20.500.12105/20232 386083700001 Asthma IgE Multimorbidity Polysensitization Rhinitis Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015