2026-06-14T03:31:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/202202024-09-22T07:07:14Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967
Repisalud
author
Di Minno, Giovanni
author
Perno, Carlo Federico
author
Tiede, Andreas
author
Navarro, David
author
Canaro Hirnyk, Mariana
author
Gueertler, Lutz
author
Ironside, James W
2024-07-09T09:12:51Z
2024-07-09T09:12:51Z
2016-01
Di Minno G, Perno Carlo F, Tiede A, Navarro D, Canaro Hirnyk M, Gueertler L, et al. Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders. Blood Rev. 2016 Jan;30(1):35-48. Epub 2015 Jul 20.
10.1016/j.blre.2015.07.004
1532-1681
0268-960X
Blood Reviews
http://hdl.handle.net/20.500.13003/17309
26381318
L606042331
2-s2.0-84960203756
http://hdl.handle.net/20.500.12105/20220
371362700005
The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community, Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations of pathogens do not necessarily imply a low level of risk for the patient and so the overall challenge of minimising risk remains. This review aims to discuss the variable level of pathogenic risk and describes the current screening methods used to prevent/detect the presence of pathogens in blood/plasma-derived products.
eng
Pathogen
Transfusion
Blood safety
Clotting
Haemophilia
Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders
review article