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oai:repisalud.isciii.es:20.500.12105/202202024-09-22T07:07:14Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16967

00925njm 22002777a 4500 dc Di Minno, Giovanni author Perno, Carlo Federico author Tiede, Andreas author Navarro, David author Canaro Hirnyk, Mariana author Gueertler, Lutz author Ironside, James W author 2016-01 The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community, Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations of pathogens do not necessarily imply a low level of risk for the patient and so the overall challenge of minimising risk remains. This review aims to discuss the variable level of pathogenic risk and describes the current screening methods used to prevent/detect the presence of pathogens in blood/plasma-derived products. Di Minno G, Perno Carlo F, Tiede A, Navarro D, Canaro Hirnyk M, Gueertler L, et al. Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders. Blood Rev. 2016 Jan;30(1):35-48. Epub 2015 Jul 20. 10.1016/j.blre.2015.07.004 1532-1681 0268-960X Blood Reviews http://hdl.handle.net/20.500.13003/17309 26381318 L606042331 2-s2.0-84960203756 http://hdl.handle.net/20.500.12105/20220 371362700005 Pathogen Transfusion Blood safety Clotting Haemophilia Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders