2026-08-25T14:09:11Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/202182024-11-28T17:50:55Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967
Repisalud
author
Aparicio, Javier
author
Carreno, Mar
author
Bargallo, Nuria
author
Setoain, Xavier
author
Rubi, Sebastia
author
Rumia, Jordi
author
Falcon, Carles
author
Calvo, Anna
author
Marti-Fuster, Berta
author
Padilla, Nelly
author
Boget, Teresa
author
Pintor, Luis
author
Donaire, Antonio
2024-07-09T09:12:50Z
2024-07-09T09:12:50Z
2016
Aparicio J, Carreno M, Bargallo N, Setoain X, Rubí S, Rumia J, et al. Combined F-18-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis. NeuroImage-Clin. 2016;12:976-89.
10.1016/j.nicl.2016.05.002
2213-1582
Neuroimage-Clinical
http://hdl.handle.net/20.500.13003/17307
27995064
L610626086
2-s2.0-84971631217
http://hdl.handle.net/20.500.12105/20218
390196400111
Objectives: Several studies using F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET) or diffusion tensor imaging (DTI) have found both temporal and extratemporal abnormalities in patients with mesial temporal lobe epilepsy with ipsilateral hippocampal sclerosis (MTLE-HS), but data are lacking about the findings of both techniques in the same patients. We aimed to determine whether the extent of F-18-FDG-PET hypometabolism is related to DTI abnormalities. Methods: Twenty-one patients with MTLE-HS underwent comprehensive preoperative evaluation; 18 (86%) of these underwent epilepsy surgery. We analyzed and compared the pattern of white matter (WM) alterations on DTI and cortical hypometabolism on F-18-FDG-PET. Results: We found widespread temporal and extratemporal F-18-FDG-PET and DTI abnormalities. Patterns of WM abnormalities and cortical glucose hypometabolism involved similar brain regions, being more extensive in the left than the right MTLE-HS. We classified patients into three groups according to temporal F-18-FDG-PET patterns: hypometabolism restricted to the anterior third (n = 7), hypometabolism extending to the middle third (n = 7), and hypometabolism extending to the posterior third (n = 7). Patients with anterior temporal hypometabolism showed DTI abnormalities in anterior association and commissural tracts while patients with posterior hypometabolism showed WM alterations in anterior and posterior tracts. Conclusions: Patients with MTLE-HS have widespread metabolic and microstructural abnormalities that involve similar regions. The distribution patterns of these gray and white matter abnormalities differ between patients with left or right MTLE, but also with the extent of the F-18-FDG-PET hypometabolism along the epileptogenic temporal lobe. These findings suggest a variable network involvement among patients with MTLE-HS.
eng
Positron emission tomography
DTI
MTLE
Hippocampus
Nerve net
Combined F-18-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis
research article