2026-06-14T03:33:17Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/202182024-11-28T17:50:55Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16961col_20.500.12105_16967

00925njm 22002777a 4500 dc Aparicio, Javier author Carreno, Mar author Bargallo, Nuria author Setoain, Xavier author Rubi, Sebastia author Rumia, Jordi author Falcon, Carles author Calvo, Anna author Marti-Fuster, Berta author Padilla, Nelly author Boget, Teresa author Pintor, Luis author Donaire, Antonio author 2016 Objectives: Several studies using F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET) or diffusion tensor imaging (DTI) have found both temporal and extratemporal abnormalities in patients with mesial temporal lobe epilepsy with ipsilateral hippocampal sclerosis (MTLE-HS), but data are lacking about the findings of both techniques in the same patients. We aimed to determine whether the extent of F-18-FDG-PET hypometabolism is related to DTI abnormalities. Methods: Twenty-one patients with MTLE-HS underwent comprehensive preoperative evaluation; 18 (86%) of these underwent epilepsy surgery. We analyzed and compared the pattern of white matter (WM) alterations on DTI and cortical hypometabolism on F-18-FDG-PET. Results: We found widespread temporal and extratemporal F-18-FDG-PET and DTI abnormalities. Patterns of WM abnormalities and cortical glucose hypometabolism involved similar brain regions, being more extensive in the left than the right MTLE-HS. We classified patients into three groups according to temporal F-18-FDG-PET patterns: hypometabolism restricted to the anterior third (n = 7), hypometabolism extending to the middle third (n = 7), and hypometabolism extending to the posterior third (n = 7). Patients with anterior temporal hypometabolism showed DTI abnormalities in anterior association and commissural tracts while patients with posterior hypometabolism showed WM alterations in anterior and posterior tracts. Conclusions: Patients with MTLE-HS have widespread metabolic and microstructural abnormalities that involve similar regions. The distribution patterns of these gray and white matter abnormalities differ between patients with left or right MTLE, but also with the extent of the F-18-FDG-PET hypometabolism along the epileptogenic temporal lobe. These findings suggest a variable network involvement among patients with MTLE-HS. Aparicio J, Carreno M, Bargallo N, Setoain X, Rubí S, Rumia J, et al. Combined F-18-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis. NeuroImage-Clin. 2016;12:976-89. 10.1016/j.nicl.2016.05.002 2213-1582 Neuroimage-Clinical http://hdl.handle.net/20.500.13003/17307 27995064 L610626086 2-s2.0-84971631217 http://hdl.handle.net/20.500.12105/20218 390196400111 Positron emission tomography DTI MTLE Hippocampus Nerve net Combined F-18-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis