2026-06-14T03:29:09Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/202142024-09-27T08:21:59Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Izzi, Benedetta
author
Fuster, Jose J.
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Fundación La Caixa
funder
Comunidad de Madrid (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2024-07-08T14:53:36Z
2024-07-08T14:53:36Z
2024-02
Hamostaseologie. 2024 Feb;44(1):13-20.
10.1055/a-2219-6410
2567-5761
Hamostaseologie
38417801
http://hdl.handle.net/20.500.12105/20214
Acquired mutations that lead to clonal hematopoiesis have emerged as a new and potent risk factor for atherosclerotic cardiovascular disease and other cardiovascular conditions. Human sequencing studies and experiments in mouse models provide compelling evidence supporting that this condition, particularly when driven by specific mutated genes, contributes to the development of atherosclerosis by exacerbating inflammatory responses. The insights gained from these studies are paving the way for the development of new personalized preventive care strategies against cardiovascular disease. Furthermore, available evidence also suggests a potential relevance of these mutation in the context of thrombosis, an area requiring thorough investigation. In this review, we provide an overview of our current understanding of this emerging cardiovascular risk factor, focusing on its relationship to atherosclerosis and thrombosis.
eng
Clonal Hematopoiesis and Cardiovascular Risk: Atherosclerosis, Thrombosis, and beyond.
journal article
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URL
https://repisalud.isciii.es/bitstreams/ebde0627-4050-4e72-a43b-e20e91c7c44c/download
File
MD5
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application/pdf
Clonal Hematopoiesis and Cardiovascular Risk_Hamostaseologie_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/d1de3980-4d30-45af-be01-c8db63b58621/download
File
MD5
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text/plain
Clonal Hematopoiesis and Cardiovascular Risk_Hamostaseologie_2024.pdf.txt