2026-06-14T05:05:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/202132024-09-27T08:21:13Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Polo-Generelo, Salvador
author
Rodríguez-Mateo, Cristina
author
Torres, Belén
author
Pintor-Tortolero, José
author
Guerrero-Martínez, José A
author
König, Julian
author
Vazquez, Jesus
author
Bonzón-Kulichenco, Elena
author
Padillo-Ruiz, Javier
author
de la Portilla, Fernando
author
Reyes, José C
author
Pintor-Toro, José A
funder
Ministerio de Ciencia e Innovación (España)
2024-07-08T14:39:26Z
2024-07-08T14:39:26Z
2024-03-06
Cell Death Discov. 2024 Mar 6;10(1):116.
10.1038/s41420-024-01886-8
2058-7716
Cell death discovery
38448406
http://hdl.handle.net/20.500.12105/20213
Serine protease inhibitor clade E member 1 (SERPINE1) inhibits extracellular matrix proteolysis and cell detachment. However, SERPINE1 expression also promotes tumor progression and plays a crucial role in metastasis. Here, we solve this apparent paradox and report that Serpine1 mRNA per se, independent of its protein-coding function, confers mesenchymal properties to the cell, promoting migration, invasiveness, and resistance to anoikis and increasing glycolytic activity by sequestering miRNAs. Expression of Serpine1 mRNA upregulates the expression of the TRA2B splicing factor without affecting its mRNA levels. Through transcriptional profiling, we found that Serpine1 mRNA expression downregulates through TRA2B the expression of genes involved in the immune response. Analysis of human colon tumor samples showed an inverse correlation between SERPINE1 mRNA expression and CD8+ T cell infiltration, unveiling the potential value of SERPINE1 mRNA as a promising therapeutic target for colon tumors.
eng
Serpine1 mRNA confers mesenchymal characteristics to the cell and promotes CD8+ T cells exclusion from colon adenocarcinomas.
journal article
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URL
https://repisalud.isciii.es/bitstreams/614ce8db-156d-4df9-b48b-3c968e7c79cc/download
File
MD5
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application/pdf
Serpine1 mRNA confers mesenchymal_Cell Death Discov_2024.pdf
URL
https://repisalud.isciii.es/bitstreams/cd5efb6c-d3de-4a87-8936-07c1b4ca5c5e/download
File
MD5
c84e9e49a6f2696b231faeded9a9cd96
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text/plain
Serpine1 mRNA confers mesenchymal_Cell Death Discov_2024.pdf.txt