2026-06-14T03:33:01Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/202132024-09-27T08:21:13Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Polo-Generelo, Salvador author Rodríguez-Mateo, Cristina author Torres, Belén author Pintor-Tortolero, José author Guerrero-Martínez, José A author König, Julian author Vazquez, Jesus author Bonzón-Kulichenco, Elena author Padillo-Ruiz, Javier author de la Portilla, Fernando author Reyes, José C author Pintor-Toro, José A author 2024-03-06 Serine protease inhibitor clade E member 1 (SERPINE1) inhibits extracellular matrix proteolysis and cell detachment. However, SERPINE1 expression also promotes tumor progression and plays a crucial role in metastasis. Here, we solve this apparent paradox and report that Serpine1 mRNA per se, independent of its protein-coding function, confers mesenchymal properties to the cell, promoting migration, invasiveness, and resistance to anoikis and increasing glycolytic activity by sequestering miRNAs. Expression of Serpine1 mRNA upregulates the expression of the TRA2B splicing factor without affecting its mRNA levels. Through transcriptional profiling, we found that Serpine1 mRNA expression downregulates through TRA2B the expression of genes involved in the immune response. Analysis of human colon tumor samples showed an inverse correlation between SERPINE1 mRNA expression and CD8+ T cell infiltration, unveiling the potential value of SERPINE1 mRNA as a promising therapeutic target for colon tumors. Cell Death Discov. 2024 Mar 6;10(1):116. 10.1038/s41420-024-01886-8 2058-7716 Cell death discovery 38448406 http://hdl.handle.net/20.500.12105/20213 Serpine1 mRNA confers mesenchymal characteristics to the cell and promotes CD8+ T cells exclusion from colon adenocarcinomas.