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oai:repisalud.isciii.es:20.500.12105/201952024-11-29T22:50:20Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Mijimolle, Nieves author Velasco, Juan author Dubus, Pierre author Guerra, Carmen author Weinbaum, Carolyn A author Casey, Patrick J author Campuzano, Victoria author Barbacid, Mariano author 2005-04 Protein farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein targets. Using gene-targeted mice, we report that FTase is essential for embryonic development, but dispensable for adult homeostasis. Six-month-old FTase-deficient mice display delayed wound healing and maturation defects in erythroid cells. Embryonic fibroblasts lacking FTase have a flat morphology and reduced motility and proliferation rates. Ablation of FTase in two ras oncogene-dependent tumor models has no significant consequences for tumor initiation. However, elimination of FTase during tumor progression had a limited but significant inhibitory effect. These results should help to better understand the role of protein farnesylation in normal tissues and in tumor development. Cancer Cell . 2005;7(4):313-24. 10.1016/j.ccr.2005.03.004 1535-6108 Cancer cell 15837621 http://hdl.handle.net/20.500.12105/20195 Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.